1,3,4-OXADIAZOLE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING THEM Russian patent published in 2023 - IPC C07D413/12 C07D413/14 A61K31/454 A61K31/4427 A61P25/00 A61P31/00 A61P3/00 A61P9/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a 1,3,4-oxadiazole derivative represented by the chemical formula I, or to a pharmaceutically acceptable salt thereof, where in the chemical formula I Z₁-Z₄ each independently represents N, CH or CX, where Z₁-Z₄ is not may be three or more N's at the same time; L, L¹ or L² are each independently -(C₀-C₂alkylene)-; R₁ represents -CX₂H or -CX₃; R₂ represents C₆ aryl, wherein at least one -H of C₆ aryl can each be independently substituted with -X, -OH, -(C₁-C₄alkyl) or -O(C₁-C₄alkyl); R represents or; R_a-R_d are each independently -H or -(C₁-C₄alkyl); R´ and R˝ are each independently -H, -(C₁-C₄alkyl), -(C₃-C₇cycloalkyl), -(C₂-C₆heterocycloalkyl) containing one O atom or one S atom in the ring, -(C₁-C₄alkyl)-(C₃-C₇cycloalkyl), -(C₁-C₄alkyl)-(C₂-C₆heterocycloalkyl), containing one O atom in the ring, -C (=O)-(C₁-C₄alkyl), -C(=O)-(C₃-C₇cycloalkyl), -C(=O)-O(C₁-C₄alkyl) or -S( =O)₂ -(C₁-C₄alkyl), wherein at least one -H of -(C₁-C₄alkyl) or -C(=O)-(C₁-C₄alkyl) may be is substituted by -X, -OH, -N(CH₃)₂ or -O(C₁-C₄alkyl) and at least one -H in the ring of -(C₃-C₇cycloalkyl) may be substituted by - X, -OH or -(C₁-C₄alkyl); m or n are each independently 1, 2 or 3; and X represents either F, Cl, Br or I. The invention also relates to a pharmaceutical composition having inhibitory activity against histone deacetylase 6 (HDAC6), based on the specified derivative of Chemical formula I.

EFFECT: obtaining new compounds and a pharmaceutical composition based on them which may have medical applications to prevent or treat HDAC6-mediated diseases, including cancer, inflammatory diseases, autoimmune diseases, neurological or neurodegenerative diseases.

9 cl, 2 tbl, 128 ex