FIELD: organic synthesis. SUBSTANCE: quinoline derivatives with general formula 1: 
(1) are provided where R1 is hydrogen, C1-6-alkyl or NR4R5 group in which R4 and R5 are hydrogen, C1-6-alkyl, phenyl or pyridyl, naphthyl, 5- or 6- membered heterocyclic group including 1-2 endonuclear nitrogen, oxygen or sulfur atoms optionally substituted by alkyl, alkoxy, halogen, hydroxy, haloalkyl, or phenyl; Z is oxygen atom, carbonyl, or methylene; E sulfur or oxygen atom; m, p, and q = 0-4. Compound possess hypoglycemic activity. EFFECT: extended choice of hypoglycemic drugs. 3 cl, 2 tbl, 28 ex
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