FIELD: medicine; pharmaceutics; organic chemistry.
SUBSTANCE: invention relates to chemistry of organic compounds, pharmacology and medicine. Disclosed is a new chemical compound, which is (Z)-(5-(4-chlorobenzylidene)-3-(2-(4-((2R,3R)-3-(2,4-difluorophenyl)-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)piperazin-1-yl)-2-oxoethyl)thiazolidine-2,4-dione and its pharmaceutically acceptable salts, characterized by high antifungal activity. Also disclosed is a pharmaceutical composition and use thereof as an antifungal agent.
EFFECT: experiments have shown that the disclosed compound is active against many strains of fungi, including those resistant to commercial azole preparations.
14 cl, 5 tbl, 3 ex
| Title |
Year |
Author |
Number |
| 3,5-SUBSTITUTED THIAZOLIDINE-2,4-DIONE DERIVATIVES, HAVING ANTIMICROBIAL ACTIVITY |
2018 |
- Levshin Igor Borisovich
- Grammatikova Nataliya Eduardovna
- Vantskul Anton Sergeevich
- Vasileva Natalya Vsevolodna
- Bogomolova Tatyana Sergeevna
|
RU2690161C1 |
| HYBRID ETHERS BASED ON DERIVATIVES OF THIAZOLIDINE-2,4-DIONA AND AZOLES (1H-1,3-IMIDAZOLE AND 1H-1,3,4-TRIAZOLE) AND APPLICATION THEREOF |
2017 |
- Levshin Igor Borisovich
- Polshakov Vladimir Ivanovich
- Grammatikova Nataliya Eduardovna
- Sandulenko Yurij Borisovich
|
RU2662153C1 |
| HYBRID AMIDES BASED ON TRIAZOLE AND THIAZOLIDINE HAVING ANTIMICROBIAL ACTIVITY |
2018 |
- Levshin Igor Borisovich
- Sandulenko Yurij Borisovich
- Polyakova Marina Vladimirovna
- Grammatikova Nataliya Eduardovna
- Vasileva Natalya Vsevolodovna
- Bogomolova Tatyana Sergeevna
|
RU2703997C1 |
| HYBRID DERIVATIVES OF (1H-1,2,4) TRIAZOLE AND SULPHUR-CONTAINING HETEROCYCLES: DERIVATIVES OF THIAZOLIDINE-2,4-DIONE, THIOMORPHOLINE-3-ONE, AND 1,4-THIAZEPAN-3-ONE, EXHIBITING ANTIMICROBIAL ACTIVITY |
2020 |
- Levshin Igor Borisovich
- Polshakov Vladimir Ivanovich
- Simonov Aleksandr Yurevich
- Grammatikova Nataliya Eduardovna
|
RU2771027C1 |
| USE OF COMPOUNDS IN TREATING FUNGAL INFECTIONS |
2021 |
- Shou, Karen Dzhoj
- Khodzhes, Majkl
|
RU2805930C1 |
| CYCLIC 5-NITROPYRIDIN-2-YL-THIOALKENYL-4-DITHIOCARBAMATE DERIVATIVES HAVING ANTIFUNGAL ACTIVITY AND USE THEREOF |
2012 |
- Surovtsev Viktor Vasilevich
- Makarov Vadim Albertovich
|
RU2487132C1 |
| ARALKYL BENSYL ETHERS, METHODS OF SYNTHESIS THEREOF, INTERMEDIATE COMPOUNDS AND THEIR USE, METHODS FOR TREATMENT AND/OR PREVENTION, PHARMACEUTICAL COMPOSITION AND DRUG ON BASIS OF THESE COMPOUNDS |
2010 |
- Keppler Artur Franz
- Zaim Marcio Henrique
|
RU2548009C2 |
| PHARMACEUTICAL COMPOSITION CONTAINING PHENYLAMIDINE DERIVATIVE, AND METHOD OF USING PHARMACEUTICAL COMPOSITION IN COMBINATION WITH ANTIMYCOTIC |
2007 |
|
RU2429843C2 |
| ANTIMICROBIAL PEPTIDES CONTAINING ARGININE- AND LYSINE-CONTAINING MOTIVE |
2005 |
|
RU2396273C2 |
| PHARMACEUTICAL COMPOSITION CONTAINING FUNGICIDE, BACTERIOSTATIC SULFONAMIDE AND ANTIBACTERIAL SUBSTANCE FOR TOPICAL USING |
2002 |
- Lukash Karoli
- Lukash Karoline
- Khegedjush Lajosh
- Krempel'S Kristina
- Dajka Levente
- Mjuller Jozef
|
RU2291694C2 |
