FIELD: medicine; pharmaceutics; organic chemistry.
SUBSTANCE: invention relates to chemistry of organic compounds, pharmacology and medicine. Disclosed is a new chemical compound, which is (Z)-(5-(4-chlorobenzylidene)-3-(2-(4-((2R,3R)-3-(2,4-difluorophenyl)-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)piperazin-1-yl)-2-oxoethyl)thiazolidine-2,4-dione and its pharmaceutically acceptable salts, characterized by high antifungal activity. Also disclosed is a pharmaceutical composition and use thereof as an antifungal agent.
EFFECT: experiments have shown that the disclosed compound is active against many strains of fungi, including those resistant to commercial azole preparations.
14 cl, 5 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 3,5-SUBSTITUTED THIAZOLIDINE-2,4-DIONE DERIVATIVES, HAVING ANTIMICROBIAL ACTIVITY | 2018 |
|
RU2690161C1 |
| COMPOSITION BASED ON ANTIFUNGAL AGENT AND MODIFIED CYCLODEXTRIN | 2023 |
|
RU2831569C1 |
| HYBRID ETHERS BASED ON DERIVATIVES OF THIAZOLIDINE-2,4-DIONA AND AZOLES (1H-1,3-IMIDAZOLE AND 1H-1,3,4-TRIAZOLE) AND APPLICATION THEREOF | 2017 |
|
RU2662153C1 |
| COMPOUNDS AND METHODS FOR TREATING FUNGAL INFECTIONS | 2021 |
|
RU2824066C1 |
| HYBRID AMIDES BASED ON TRIAZOLE AND THIAZOLIDINE HAVING ANTIMICROBIAL ACTIVITY | 2018 |
|
RU2703997C1 |
| HYBRID DERIVATIVES OF (1H-1,2,4) TRIAZOLE AND SULPHUR-CONTAINING HETEROCYCLES: DERIVATIVES OF THIAZOLIDINE-2,4-DIONE, THIOMORPHOLINE-3-ONE, AND 1,4-THIAZEPAN-3-ONE, EXHIBITING ANTIMICROBIAL ACTIVITY | 2020 |
|
RU2771027C1 |
| USE OF COMPOUNDS IN TREATING FUNGAL INFECTIONS | 2021 |
|
RU2805930C1 |
| CYCLIC 5-NITROPYRIDIN-2-YL-THIOALKENYL-4-DITHIOCARBAMATE DERIVATIVES HAVING ANTIFUNGAL ACTIVITY AND USE THEREOF | 2012 |
|
RU2487132C1 |
| CHIMERIC RECOMBINANT INTERFERON ALPHA-2B, HAVING ANTIFUNGAL ACTIVITY | 2024 |
|
RU2823607C1 |
| ARALKYL BENSYL ETHERS, METHODS OF SYNTHESIS THEREOF, INTERMEDIATE COMPOUNDS AND THEIR USE, METHODS FOR TREATMENT AND/OR PREVENTION, PHARMACEUTICAL COMPOSITION AND DRUG ON BASIS OF THESE COMPOUNDS | 2010 |
|
RU2548009C2 |
