MONOCLONAL ANTIBODY IC1 AND ITS ANTIGEN-BINDING FRAGMENT, SELECTIVELY BINDING RECEPTOR-BINDING DOMAIN OF SPIKE PROTEIN OF SARS-CoV-2 VIRUS, HAVING VIRUS-NEUTRALIZING ACTIVITY Russian patent published in 2024 - IPC C07K16/10 C07K14/165 C12N15/13 

Abstract RU 2817696 C1

FIELD: biotechnology.

SUBSTANCE: described is a group of inventions which includes a monoclonal antibody iC1 and its antigen-binding fragment, which selectively bind the receptor-binding domain (RBD) of the Spike protein of the SARS-CoV-2 virus, having virus-neutralizing activity. In one version of the invention, the monoclonal antibody or its antigen-binding fragment comprises a heavy chain variable region (VH) containing the amino acid sequence SEQ ID NO: 3, and a light chain variable region (VL) containing the amino acid sequence SEQ ID NO: 4.

EFFECT: invention is aimed at development of a new monoclonal antibody binding to RBD of the Spike protein of the SARS-CoV-2 virus, having high affinity and capable of neutralizing SARS-CoV-2 virus.

7 cl, 7 dwg, 4 tbl, 7 ex

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RU 2 817 696 C1

Authors

Baranov Konstantin Olegovich

Belovezhets Tatyana Nikolaevna

Volkova Olga Yurevna

Gorchakov Andrej Aleksandrovich

Guselnikov Sergej Vladimirovich

Kulemzin Sergej Viktorovich

Mechetina Lyudmila Vasilevna

Nayakshin Aleksandr Matveevich

Solodkov Pavel Pavlovich

Taranin Aleksandr Vladimirovich

Chikaev Anton Nikolaevich

Chikaev Nikolaj Andreevich

Dates

2024-04-18Published

2023-11-22Filed