METHOD FOR DIAGNOSING PLACENTA INGROWTH INTO UTERINE WALL IN WOMEN WITH PLACENTA PREVIA Russian patent published in 2022 - IPC G01N33/68 G01N33/573 

FIELD: medicine; obstetrics and gynecology.

SUBSTANCE: invention relates to medicine, namely to obstetrics and gynecology; it can be used for diagnosing placenta ingrowth into the uterine wall in women with placenta previa. Immunoassay analysis of the blood serum of a pregnant woman is conducted. In a complex, the level of pregnancy-associated plasma protein-A (hereinafter – PAPP-A), expressed in multiple of median (hereinafter – MoM), is determined in 11-13 weeks of pregnancy; the concentration of soluble fms-like tyrosine kinase-1 (hereinafter – sFlt-1) in pg/ml, placenta growth factor (hereinafter – PlGF) in pg/ml is determined once in the 3^rd trimester of pregnancy. A coefficient C1 – the ratio of sFlt-1 concentration to PlGF concentration – is calculated. The, an indicator P is determined as the ratio of PAPP-A level expressed in MoM to the coefficient C1. A coefficient C2 is determined as a number of caesarean sections (N CS) in a pregnant woman in the anamnesis plus conventional unit (+1). Then, the presence of placenta ingrowth (PC) is determined as the result of multiplication of the sum of P and conventional unit (+1) by C2: PC = (P+1) × C2. When PC is more than 3.30, the presence of placenta ingrowth is determined.

EFFECT: method provides for the possibility of increasing the specificity of prediction of placenta ingrowth due to a complex assessment of biomarkers of pathological placentation of the 1^st and the 3^rd trimesters of pregnancy, as well as increasing the reproduction of the results due to the use of indicators independent of variety of measurements performed on specific equipment.

1 cl, 3 tbl, 2 ex