METHOD FOR THE PREVENTION OR THERAPY OF ACUTE RESPIRATORY DISTRESS SYNDROME USING A MODEL OF INDUCED ARDS IN LABORATORY ANIMALS Russian patent published in 2022 - IPC A61K38/10 A61P11/00 A61K49/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine and concerns a method for the prevention or therapy of acute respiratory distress syndrome on a model of induced ARDS in laboratory animals, modeled using lipopolysaccharide, by its endotracheal administration, followed by induction of an inflammatory cellular signaling pathway and the use of experimental prevention or therapy of ARDS, consisting in the introduction before or after ARDS modeling of a drug based on ezrin-peptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu at a dose of 0.2 mg to 1 mg per animal.

EFFECT: invention provides a reduction in the risk of dependence of the results of therapy on the methods for administration of the drug; reduction of the toxic effects of ARDS therapy; increased resistance of the body in the treatment of ARDS against infections caused by viruses, bacteria and fungi; inhibition of inflammatory cytokines that cause ARDS.

3 cl, 3 ex