PRODUCT AND METHOD FOR MUCUS VISCOSITY NORMALIZATION Russian patent published in 2021 - IPC A61K38/46 A61P11/12 

FIELD: medicine; therapy.

SUBSTANCE: group of inventions can be used to reduce mucus viscoelasticity or sputum in a patient with excessively viscous or sticky mucus or sputum. For this purpose, mucus or sputum of said patient is brought into contact with a composition containing a protein or peptide containing a mono-cystine active center of thioredoxin in a reduced state, wherein the thioredoxin mono-cystine active center comprises an amino acid sequence selected from a group consisting of C-X-X-S (SEQ ID NO: 24), C-X-X-X (SEQ ID NO: 17), X-C-X-X-X-X (SEQ ID NO: 19), X-C-G-P-X-X (SEQ ID NO: 21), W-C-G-P-X-K (SEQ ID NO: 23), X-C-X-X-S-X (SEQ ID NO: 25), X-C-G-P-S-X (SEQ ID NO: 26) and W-C-G-P-S-K (SEQ ID NO: 27), wherein said residue C is in a reduced state, wherein said residues X are any amino acid residue other than cysteine. Also disclosed are methods, pharmaceutical compositions and use thereof for converting a disulphide bond of a target protein into a stable mixed disulphide bond, to maintain stable mixed disulphide bond, for its conversion into stable mixed disulphide bond.

EFFECT: group of inventions makes it possible to increase effectiveness of mucus or sputum liquefaction due to covalent binding with mucin cysteine at safety and good tolerance.

49 cl, 3 dwg, 3 tbl, 9 ex