METHOD FOR ACCELERATING POST-RADIATION RECOVERY OF SPLEEN IN LABORATORY ANIMALS Russian patent published in 2022 - IPC A61K35/28 A61K31/711 A61P43/00 

FIELD: experimental medicine.

SUBSTANCE: invention relates to experimental medicine, namely to the development of methods for accelerating the process of post-radiation recovery of the spleen, and can be used to restore the body after radiation exposure in oncological diseases. The method includes intravenous administration of mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) with an injection interval of 24 hours. Mesenchymal stem cells are administered at a dose of 1∙10⁶ cells/mouse during the first hour after irradiation, and hematopoietic stem cells - 0.3∙10⁶ myelokaryocytes/mouse. Additionally, Derinat is administered intramuscularly three times at a dose of 0.13 mg/g of live weight 10-15 minutes after irradiation, on days 3 and 7.

EFFECT: invention improves the results of post-radiation recovery of the spleen of laboratory animals, strengthens the immune status of irradiated animals.

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