FIELD: medicine.
SUBSTANCE: method is realised by the intravenous allogeneic transplantation of multipotent mesenchymal stromal cells (MMSC) and hematopoietic stem cells (HSC) to laboratory mice one hour after irradiation. HSC are obtained from the placenta of female mice at the 14-day gestation term. MMSC are introduced in a dose of 6.5 mln cells/kg, with HSC being introduced in a dose of 400 thousand cells/kg.
EFFECT: invention makes it possible to extend the arsenal of means, capable of providing the regeneration potential of the spleen tissues, as well as to increase the regeneration of main morphometric spleen indices after exposure to a radiation load.
2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR SPLEEN LYMPHOID TISSUE RECONSTRUCTION IN LABORATORY ANIMALS | 2016 |
|
RU2639404C1 |
| METHOD FOR INCREASING REGENERATION ACTIVITY OF RAT'S INTESTINAL EPITHELIUM FOLLOWING RADIATION EXPOSURE | 2013 |
|
RU2524804C1 |
| METHOD OF ACTIVATING ERYTHROPOESIS OF LABORATORY ANIMALS AFTER RADIATION EXPOSURE | 2017 |
|
RU2654228C1 |
| METHOD FOR ACTIVATING MYELOID TISSUE REGENERATION IN OLD LABORATORY ANIMALS | 2013 |
|
RU2523574C1 |
| METHOD FOR RECOVERING BIOCHEMICAL PARAMETERS OF PERIPHERAL BLOOD OF LABORATORY ANIMALS WITH HEPATIC CIRRHOSIS | 2019 |
|
RU2729931C1 |
| METHOD FOR ACCELERATING POST-RADIATION RECOVERY OF SPLEEN IN LABORATORY ANIMALS | 2021 |
|
RU2774030C1 |
| METHOD OF RESTORING MYELOID TISSUE OF OLD LABORATORY ANIMALS AFTER INFLUENCE OF IONISING IRRADIATION | 2008 |
|
RU2394585C1 |
| METHOD OF JEJUNAL EPITHELIUM PERAIR IN LABORATORY ANIMALS EXPOSED TO IONISING RADIATION | 2009 |
|
RU2415476C2 |
| METHOD FOR RECOVERING BIOCHEMICAL INDICES OF PERIPHERAL BLOOD OF LABORATORY ANIMALS WITH TOXIC HEPATITIS | 2020 |
|
RU2739855C1 |
| METHOD OF THE TREATMENT OF LIVER FIBROSIS BY ALLOGENEIC TRANSPLANTATION OF MULTIPOTENT MESENCHYMAL STROMAL CELLS (MMSC) OF LABORATORY ANIMALS | 2022 |
|
RU2802673C1 |
