GRISEOFULVIN COMPOUND AND ITS PHARMACEUTICAL APPLICATION Russian patent published in 2022 - IPC C07D307/94 A61K31/343 A61K31/351 A61K31/4155 A61K31/424 A61K31/4245 A61K31/438 A61K31/443 A61K31/454 A61K31/506 A61P3/04 A61P21/02 A61P25/00 A61P25/02 A61P25/08 A61P25/14 A61P25/16 A61P29/00 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to griseofulvin derivatives, a pharmaceutical composition based on them, as well as to the use of a pharmaceutical composition for the prevention and/or treatment of an inflammatory disease of the central nervous system. The composition contains a compound of the general formula (1’) or its pharmacologically acceptable salt, where R¹ is a C1-C6 alkyl group optionally substituted with the same or different one or two substituents selected from a substituent X group, R² is a C1-C6 alkyl group, A is a 5-element aromatic heterocyclic ring selected from pyrazolyl and oxadiazolyl, a 6-element aromatic heterocyclic ring selected from pyridinyl and pyrimidinyl, or a single bond (if a single bond, then one or the other of R³ and R^3’ is absent); R³ and R^3’, each independently, is a hydrogen atom, a hydroxy group, a C1-C6 alkyl group optionally substituted with the same or different one or two substituents selected from the substituent X group, a C1-C6 alkoxy group optionally substituted with the same or different one or two substituents selected from the substituent X group, a 6-element aromatic heterocyclic group selected from piperidinyl and tetrahydropyranyl, optionally substituted with the same or different one or two substituents selected from the substituent X group, or R³ and R^3’ can form a 6-element unsaturated heterocyclic ring as a ring that binds and condenses with A, and the specified ring is optionally substituted with the same or different one or two substituents selected from the substituent X group, the substituent X group is a halogen atom, a hydroxy group, C1-C6 alkyl group, C1-C6 alkoxy group.

EFFECT: new compounds are obtained, as well as a pharmaceutical composition based on them, which can be used in medicine for the treatment of an inflammatory disease of the central nervous system.

17 cl, 4 dwg, 17 tbl, 25 ex