ANTITUMOR AGENT Russian patent published in 2022 - IPC A61K31/4245 A61K31/45 C07D271/06 A61P35/00 

Abstract RU 2770824 C2

FIELD: medicine; pharmaceutics.

SUBSTANCE: group of inventions relates to the field of medicine and pharmaceutics and concerns sulfonamide compounds for the treatment and/or prevention of tumors. For this purpose, a pharmaceutical composition is developed, containing the effective amount of a sulfonamide compound represented by the formula (I), where X1 is an oxygen atom; X2 is an oxygen atom; X3 is -NH-; X4 is a hydrogen atom; R1 is -C(R11)(R12)-; one of R11 and R12 is a hydrogen atom, and the other is a methyl group; R2 is a phenyl group having R21 as a substituent; R21 is a halogen atom or C1-C6 alkyl group (when two or more of R21 are present, R21 are the same or different from each other); R3 is a phenyl group having R31 as a substituent, or a chromanyl group having Rc as a substituent; R31 is a halogen atom or an aminocarbonyl group (when two or more of R31 are present, R31 are the same or different from each other ); Rc is a halogen atom, a hydroxy group, or C1-C6 alkyl group (when two or more of Rc are present, Rc are the same or different from each other), and R4 is a hydrogen atom; or its pharmaceutically acceptable salt and at least another antitumor agent. An agent for enhancing the antitumor effect of another antitumor agent, an antitumor agent for the treatment of a cancer patient receiving another antitumor agent, a sulfonamide compound, and methods for the treatment and/or prevention of cancer are also disclosed.

EFFECT: resulting compounds have the activity of inhibiting ribonucleotide reductase (RNR) and enhance the antitumor effect when used together with another compound having an antitumor effect.

36 cl, 4 dwg, 51 tbl, 355 ex

Similar patents RU2770824C2

Title Year Author Number
SULPHONAMIDE COMPOUND OR SALT THEREOF 2017
  • Miyahara, Seiji
  • Ueno, Hiroyuki
  • Hara, Shoki
  • Ogino, Yoshio
RU2732572C2
SULFONAMIDE COMPOUNDS AND THEIR USE 2018
  • Nakamura, Hiroyuki
  • Teng, Jing
  • Gignac, Nathan
RU2781383C2
HETEROAROMATIC MODULATORS OF RETINOL-BOUND ORPHAN GAMMA RECEPTOR 2017
  • Jessiman, Alan Stuart
  • Johnson, Patrick Stephen
  • Maansson, Kristoffer
  • Sorensen, Morten Dahl
RU2771280C2
NOVEL PHENYL PYRROLE DERIVATIVE 2009
  • Furukava Akikhiro
  • Fukuzaki Takekhiro
  • Onisi Jukari
  • Kobajasi Khideki
  • Khonda Takesi
  • Matsui Jumi
  • Konisi Masakhiro
  • Ueda Kendziro
  • Matsufudzi Tetsujosi
RU2470917C2
CONDENSED QUINOLINE DERIVATIVE AND USE THEREOF 2005
  • Kadzino Masakhiro
  • Kherd Nikolas Uill'Jam
  • Tarui Naoki
  • Banno Khirosi
  • Kavano Jasukhiko
  • Inatomi Nobukhiro
RU2384571C2
2,4-PYRIMIDINDIAMINE COMPOUNDS HAVING EFFECT IN CASE OF AUTOIMMUNE DISORDERS 2004
  • Radzhinder Singkh
  • Ankush Argade
  • Li Khoj
  • Bkhamidipati Somasekkhar
  • Kehrroll Dehvid
  • Sil'Vehn Katrin
  • Klaf Dzheffri
  • Kajm Khol'Ger
RU2356901C2
DIAMINE DERIVATIVES 2003
  • Okhta Tosikharu
  • Komorija Satosi
  • Josino Tosikharu
  • Uoto Kouiti
  • Nakamoto Jumi
  • Naito Khirojuki
  • Motizuki Akijosi
  • Nagata Tsutomu
  • Kanno Khidejuki
  • Khaginoja Norijasu
  • Josikava Kendzi
  • Nagamoti Masatosi
  • Kobajasi Siozo
  • Ono Makoto
RU2333203C2
DERIVATIVES OF HYDROXAMIC OR CARBOXYLIC ACID AND PHARMACEUTICAL OR VETERINARY COMPOSITION ON SAID 1995
  • Bekket Rajmond Pol'
  • Uittaker Mark
  • Miller Ehndrju
  • Martin Fiona Mitchell
RU2136657C1
METHODS FOR TREATMENT OR PREVENTION OF AUTOIMMUNE DISEASES WITH USE OF 2,4-PYRIMIDINEDIAMINE 2013
  • Singkh, Radzhinder
  • Argade, Ankush
  • Pejan, Donald, Dzh.
  • Klaf, Dzheffri
  • Kajm, Kholger
  • Silven, Katrin
  • Li, Khuej
  • Bkhamidipati, Somasekkhar
RU2659777C2
CYCLOALKANE DERIVATIVE 2013
  • Sinozuka Tsuesi
  • Kobayasi Khiroyuki
  • Suzuki Sayaka
  • Tanaka Kesuke
  • Kimoto Khiroko
  • Domon Yuki
RU2635354C2

RU 2 770 824 C2

Authors

Ueno, Hiroyuki

Hoshino, Takuya

Dates

2022-04-22Published

2018-11-28Filed