STILBENE DERIVATIVE AND ITS PRODUCTION METHOD Russian patent published in 2022 - IPC C07C255/42 C07C255/41 C07C255/35 C07C253/30 C07D241/04 A61K31/496 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a stilbene derivative of the chemical formula 1 or its pharmaceutically acceptable salt for the suppression of cyclophilin function and a pharmaceutical composition based on them. In the chemical formula 1, A is CRa, B is CRb, G is Cre, J is CRf, M is CRg, D, E, and L are CRh, Rx is H, Ra is a hydrogen atom or C1-C5 alkyl group, Rb is a hydrogen atom, Rc is -CH₂C(CH₃)₃, Rd is COOH or -COOR5 (R5 is C1-C10 alkyl group or C3-C10 cycloalkyl group, where C1-C10 alkyl group can be substituted with at least one substituent selected from a group consisting of an amino group, C6-C12 aryl, C5-C10 heterocyclic group including nitrogen as a heteroatom, and C3-C10 cycloalkyl group), Re is a hydrogen atom, NH₂, OH or C1-C10 alkyl group, Rf is a hydrogen atom, NH₂, OH or C1-C4 alkyl group, Rg is a hydrogen atom, NH₂, OH, C1-C10 alkyl group or -COORz (Rz is C1-C10), and Rh is a hydrogen atom, NH₂, OH or C1-C5 alkyl group.

EFFECT: providing stilbene derivatives for the suppression of cyclophilin function.

[Chemical formula 1]

4 cl, 10 tbl, 6 ex