19-NOR NEUROACTIVE STEROIDS AND METHODS OF USING THEM Russian patent published in 2019 - IPC C07J43/00 A61K31/58 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof. In formula (I) is a single or double bond, as valence allows; A has formula (A-1) or formula (A-2), where attachment point is in G¹ or G² in formula (A-1) and attachment point is in G² or G³ in formula (A-2); G¹ is N, NR^N1 or CR^G1, as valence allows; G² is N or -C=N-, as valence allows; G³ is N or CR^G3, as valence allows; G⁴ is N or CR^G4, as valence allows; G⁵ is N or CR^G5, as valence allows; G⁶ is N or CR^G6, as valence allows; and G⁷ is N or CR^G7, as valence allows; in each case R^G1, R^G2, R^G3, R^G4, R^G5, R^G6 and R^G7 independently represents hydrogen, halogen, -CN, -OR^GA or unsubstituted C_1-6 alkyl; in each case R^N1 is unsubstituted C_1-6 alkyl; in each case R^GA independently represents hydrogen, C_1-6 alkyl substituted with fluorine or unsubstituted C_1-6 alkyl; R¹ is C_1-6 alkyl substituted with fluorine, methoxy or ethoxy, or unsubstituted C_1-6 alkyl; R² is hydrogen; R^3a is hydrogen and R^3b is hydrogen; each R^4a or R^4b independently represents hydrogen; provided that if the bond p is a double bond, then the bond q is a single bond, provided that if the bond q is a double bond, then the bond p is a single bond and R^4b is absent; and provided that both bonds q and p are single bonds, hydrogen in C5 is in alpha or beta configuration. Invention also refers to pharmaceutical salts of compounds, to a pharmaceutical composition, to individual compounds and their pharmaceutically acceptable salts.

, (A-1), (A-2).

EFFECT: obtaining novel compounds of formula (I), having the GABA modulator property.

21 cl, 13 dwg, 3 tbl, 95 ex