NEUROACTIVE STEROIDS, COMPOSITIONS AND USE THEREOF Russian patent published in 2019 - IPC C07J43/00 A61K31/57 A61K31/58 A61P23/00 A61P25/08 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I), in which A is 5-member heteroaryl with 2–4 nitrogen atoms, 5,6-bicyclic heteroaryl with 2–4 nitrogen atoms or 6-member heterocyclyl with 2 heteroatoms independently selected from nitrogen and oxygen, where A is attached through nitrogen and optionally substituted with 1–4 substitutes, each of which is independently selected from cyano, halogen, C₁-C₆-alkyl, C₁-C₆-halogenalkyl, C₁-C₆-alkoxy, -OC₁-C₆-halogenalkyl, -C(O)R^a, -C(O)OR^a and -S(O)2R^a; each Ra is C₁-C₆-alkyl; L is -C (R³)(R³) -; R¹ is hydrogen or C₁-C₆ alkyl; R² is hydrogen, C₁-C₆ alkyl or C₁-C₆ haloalkyl; each R³ is hydrogen; R⁵ is hydrogen; and is a single bond. Invention also relates to use of compound of formula (I).

(I).

EFFECT: technical result is obtaining novel compounds of formula (I), having modulating GABA activity.

38 cl, 3 tbl, 92 ex