BINDING MOLECULES SPECIFIC TO IL-21 AND THEIR USE Russian patent published in 2023 - IPC C07K16/24 C07K14/54 A61K39/395 C07K17/00 

FIELD: biotechnology.

SUBSTANCE: group of inventions is described, including an antibody or its antigen-binding fragment that specifically binds to IL-21, a conjugate for the treatment or prevention of a disease or disorder associated with IL-21, containing an antibody or antigen-binding fragment, a pharmaceutical composition for the treatment or prevention of a disease or disorder, associated with IL-21, containing an antibody or antigen-binding fragment or conjugate, and a method of treating or preventing a disease or disorder associated with IL-21 in a subject in need thereof. In one embodiment, the antibody comprises a heavy chain variable region (VH) CDR1, CDR2 and CDR3 with the amino acid sequences of the following SEQ ID NO: 29, the following SEQ ID NO: 30 and the following SEQ ID NO: 31, respectively; and CDR1, CDR2 and CDR3 of the light chain variable region (VL) with the amino acid sequences of the following SEQ ID NO: 34, the following SEQ ID NO: 35 and the following SEQ ID NO: 36 respectively.

EFFECT: invention expands the arsenal of agents that specifically bind to IL-21.

15 cl, 40 dwg, 7 tbl, 5 ex