TREATMENT OF CANCER, USING ANTIBODY TO SEMAPHORIN 4D IN COMBINATION WITH EPIGENETIC MODULATING AGENT Russian patent published in 2022 - IPC A61K39/395 A61P35/00 C07K16/28 

Abstract RU 2783535 C2

FIELD: biotechnology.

SUBSTANCE: group of inventions is described, including a pharmaceutical composition for inhibition, delay, or reduction in growth of malignant cells in subject suffering from cancer (options), and a method for inhibition, delay, or reduction in growth of malignant cells in a subject suffering from cancer, including administration to the subject of the above-mentioned pharmaceutical composition. In one of implementations, the pharmaceutical composition contains effective amount of an antibody or its antigen-binding fragment, specifically binding to semaphorin 4D (SEMA4D), and epigenetic modulating agent selected from entinostat and azacytidine.

EFFECT: invention expands the arsenal of means for inhibition, delay, or reduction in growth of malignant cells in a subject suffering from cancer.

26 cl, 12 dwg, 4 tbl, 3 ex

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RU 2 783 535 C2

Authors

Evans, Elizabet

Smit, Ernest S.

Zauderer, Moris

Dates

2022-11-14Published

2018-03-14Filed