NATURAL KILLER CELL CONTAINING EXOGENOUS MITOCHONDRIA, AND PHARMACEUTICAL COMPOSITION INCLUDING SUCH A CELL Russian patent published in 2022 - IPC C12N5/783 A61K35/17 A61K9/08 A61P35/00 

FIELD: cell biology; medicine.

SUBSTANCE: present invention relates to the field of cell biology and medicine, in particular to cytotoxic natural killer (hereinafter – NK) cells containing exogenous mitochondria, as well as to a composition and a method for the treatment of malignant tumor, such as stomach cancer, liver cancer, lung cancer, colorectal cancer, breast cancer, prostate cancer, ovarian cancer, pancreatic cancer, cervical cancer, thyroid cancer, laryngeal cancer, acute myeloid leukemia, brain tumor, neuroblastoma, reninoblastoma, head and neck cancer, salivary gland cancer and lymphoma, or an infection disease, such as hepatitis B, hepatitis C, HPV, cytomegalovirus infection, virus respiratory diseases, and influenza. The specified exogenous mitochondria can be obtained from muscle cells, hepatocytes, fibroblasts, epithelial cells, neurons, adipocytes, osteocytes, leukocytes, lymphocytes, monocytes, stem cells, or mucous membrane cells.

EFFECT: present invention allows for an increase in cytotoxicity of NK cells, contributing to enhancing of the immune system of a human body for the improvement of their therapeutic effect.

8 cl, 13 dwg, 13 ex