FIELD: cell biology; medicine.
SUBSTANCE: present invention relates to the field of cell biology and medicine, in particular to a method for the transfer of NK-cells to the bone marrow of a patient, and a method for the treatment of malignant neoplasm of the bone marrow. For the implementation of the specified methods, NK-cells are brought into contact with particles PM21 and/or feeding cells FC21 before the transfer of NK-cells to the body of the specified subject, and then, NK-cells are administered to the specified subject. In this case, the transfer of NK-cells to the bone marrow and, consequently, treatment is carried out due to that the specified contact of NK-cells with particles PM21 and/or feeding cells FC21 induces in NK-cells a cell mechanism inducing fucosylation of PSGL-1 on the surface of NK-cells.
EFFECT: present invention allows for the improvement of the efficiency of directed migration (homing) of NK-cells to bone marrow.
12 cl, 34 dwg, 2 ex
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