SUPPRESSION OF TUMORS USING HUMAN PLACENTA DERIVED INTERMEDIATE NATURAL KILLER CELLS AND IMMUNOMODULATING COMPOUNDS Russian patent published in 2021 - IPC A61K35/50 A61K35/51 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention refers to a method of treating an individual. Method of treating an individual suffering from a malignant tumor, comprising administering to said individual recovered natural killer cells containing recovered CD56+, CD16−, CD3− natural killer cells derived from placenta, where said placental intermediate natural killer cells are recovered from placental perfusate and express one or more micro-RNAs hsa-miR-100, hsa-miR-127, hsa-miR-211, hsa-miR-302c, hsa-miR-326, hsa-miR-337, hsa-miR-497, hsa-miR-512-3p, hsa-miR-515-5p, hsa-miR-517b, hsa-miR-517c, hsa-miR-517c. 518a, HSA-mir-518e, HSA-mir-519d, HSA-mir-520g, HSA-mir-520h, hsa-miR-564, hsa-miR-566, hsa-miR-618 or hsa-mir-99A at a detectably higher level than natural killer cells of peripheral blood.

EFFECT: above described method is effective in treating tumorous diseases.

1 cl, 12 dwg, 20 tbl, 8 ex