COBALAMIN DERIVATIVES AND THEIR USE FOR TREATMENT OF DISEASES CAUSED BY LACK OF VITAMIN B INTAKE Russian patent published in 2022 - IPC C07H23/00 A61K31/714 A61P25/28 

Abstract RU 2777536 C2

FIELD: medicine.

SUBSTANCE: present invention relates to a cobalamin derivative of the formula (I), in which X is ligand with the formula selected from a group consisting of -(CH2)1-5-S-(CH2)0-3-CH3, -S-(CH2)1-5-NH2, , where R1 = H, methyl, or ethyl, R2 = , and R3 = -H, or . A pharmaceutical composition, a food additive, a method for the production of a cobalamin derivative, and its use are also proposed.

EFFECT: proposed cobalamin derivatives of the formula (I) are useful for the treatment of vitamin B12-related disorders caused by either reduced vitamin B12 intake from food to cells that need it, or a genetic defect, or another obstacle in the way of transfer and intracellular recycling of B12.

12 cl, 15 dwg, 6 tbl, 16 ex

Similar patents RU2777536C2

Title Year Author Number
COBALAMIN DERIVATIVES USED FOR DIAGNOSIS AND TREATMENT ANOMALOUS CELL PROLIFERATION 2004
  • Trajkhler Khans-Jerg
  • Al'Berto Rozhe
  • Vajbel' Robert
  • Kjuehntsi Martin T.
  • Njuehsh Jakob
  • Mundviler Shtefan
  • Van-Staveren Dave R.
RU2394042C2
COMPOSITIONS AND METHODS FOR PREVENTING AND/OR TREATING VITAMIN B12 DEFICIENCY 2017
  • De Vos, Willem Meindert
RU2730870C2
POLYMER-ASSISTED AMPLIFICATION OF VITAMIN B ABSORPTION SYSTEM 1994
  • Gregori Dzhon Rassell-Dzhons
  • Stiven Uill'Jam Vestvud
  • Alison Rat Gould
  • Bernard Vinsent Makajnerni
RU2139732C1
EXTERNAL COMPOSITIONS CONTAINING ADENOSYL COBALAMIN FOR TREATMENT OF SKIN DISEASES 2006
  • Shin Bjung Cheol
  • Seong Khasoo
  • Li Aeri
  • Kong Zhae Jang
  • Cheon Khjaae Gjaeong
  • Cho Jung Sik
  • Zhun Sung Soo
  • Zho Jung Gvan
RU2379039C2
ORAL THERAPY OF VITAMIN B DEFICIENCY 2011
  • Kastelli Kristina
RU2576511C2
METHOD FOR COMBINED SURGICAL APPLICATION OF FLY LARVAE 2015
  • Morozov Artem Mikhajlovich
RU2571062C1
METHOD FOR IDENTIFYING PERSON WITH THE RISK OF NON REVERSIBLE NEUROLOGICAL LESIONS INCLUDING STAGES FOR QUANTITATIVE DETECTION OF PEPSINOGEN I (PG I) AND VITAMIN B 12 CONCENTRATIONS 2000
  • Sipponen Pentti
  • Khjarkenen Matti
  • Suovaniemi Osmo
  • Forsblom Ehrik
RU2224258C2
COMBINED AGENT BASED ON NSIAD, MUSCLE RELAXANT AND VITAMIN 2017
  • Chekalov Aleksej Valerevich
RU2711624C2
METHOD FOR NORMALIZING METABOLISM IN DOMESTIC ANIMALS 2003
  • Malkov M.A.
  • Dan'Kova T.V.
  • Barabanshchikova G.V.
  • Dan'Kov P.I.
  • L'Vova L.E.
RU2266739C2
CONJUGATE CONTAINING FOLIC ACID AND INDOLE-3-CARBINOL FOR MEDICAL USE 2014
  • Terenzio Domenico
  • Rastrelli Luca
RU2692078C2

RU 2 777 536 C2

Authors

Hannibal Luciana

Dates

2022-08-08Published

2018-05-24Filed