METHOD FOR PRODUCTION OF PARP INHIBITOR AND ITS INTERMEDIATE COMPOUND Russian patent published in 2022 - IPC C07D487/04 A61K31/4985 A61P35/00 

Abstract RU 2777597 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method for the production of a compound represented by the formula I, where the method includes a stage of a reaction of a compound represented by the formula II' with a compound represented by the formula IV, and a stage of a reaction of a compound represented by the formula II with corresponding acid to obtain the compound represented by the formula II'.

where R1 is CF3; Ra is selected from hydroxyl, halogen, or alkoxy; X is selected from hydrochloric acid, phosphoric acid, and maleic acid.

EFFECT: new method is developed, which is characterized by high yield, good product purity, and is more suitable for the industrial production.

7 cl, 7 ex

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RU 2 777 597 C2

Authors

Li, Wenhai

Zhang, Yingjie

Dates

2022-08-08Published

2019-01-08Filed