INJECTION COMPOSITION CONTAINING A CONJUGATE OF FILLER WITH POLY-L-LACTIC ACID AND FILLER WITH HYALURONIC ACID, AND METHOD OF ITS PREPARATION Russian patent published in 2022 - IPC A61L27/26 A61L27/44 A61L27/54 C08J3/75 

FIELD: injectable sustained release formulation.

SUBSTANCE: invention relates to an injectable sustained release formulation. The method for obtaining a filler includes the following steps: (a) PLLA is mixed with CMC and mannitol, freeze-dried, crushed to a certain size and sterilized using gamma radiation; (b) mixing the HA with the BDDE crosslinker, gelling, washing with phosphate buffer, collecting the crosslinked HA with identical particles, and passing the HA through a sieve; (c) dissolving the PLLA mixture in an organic solvent to give an oil phase; (d) adding distilled water to cross-linked HA, obtaining an aqueous phase; (e) mixing the oil phase with the aqueous phase to form an emulsion; (f) spraying drying the emulsion; where freeze drying in step (a) includes: performing the main freeze drying at a temperature of -60 to -100°C for 12-24 hours; performing additional drying at a temperature of 15-25°C for 5-10 days, the size of the crushed particles is in the range of 30-100 microns.

EFFECT: invention provides improved initial volume and suspension uniformity.

3 cl, 3 ex