FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to a method for the protection of pig fetus from the infection with the porcine reproductive and respiratory syndrome virus (hereinafter – PRRSV), including breeding of a female pig with a male pig. At the same time, the female pig contains modified chromosome sequences in both alleles of gene CD163, wherein the modified chromosome sequence is an insert in a gene encoding protein CD163, deletion in the gene encoding protein CD163, or a combination thereof.
EFFECT: invention is effective for the reduction in sensitivity of a female pig to infection with PRRSV.
31 cl, 24 dwg, 18 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANIMALS RESISTANT TO PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS | 2012 |
|
RU2644673C2 |
| PRRS VIRUSES, THEIR INFECTIOUS CLONES, MUTANT FORMS AND METHODS OF APPLICATION | 2006 |
|
RU2427646C2 |
| B4GALT1 OPTIONS AND THEIR APPLICATIONS | 2018 |
|
RU2805557C2 |
| RNA-guided destruction of human JC virus and other poliomaviruses | 2015 |
|
RU2747722C2 |
| CRISPR-CAS SYSTEMS AND METHODS OF CHANGING EXPRESSION OF GENE PRODUCTS | 2013 |
|
RU2687451C1 |
| METHODS AND COMPOSITIONS FOR THE TREATMENT OF DISORDERS AND DISEASES RELATED TO RDH12 | 2017 |
|
RU2764920C2 |
| METHODS AND COMPOSITIONS FOR TREATING HUNTINGTON'S DISEASE | 2015 |
|
RU2691102C2 |
| COMPOSITIONS AND METHODS FOR REDUCTION OF LEVEL OF HS IN FERMENTED BEVERAGES | 2008 |
|
RU2476590C2 |
| GENE EDITING OF DEEP INTRON MUTATIONS | 2016 |
|
RU2759335C2 |
| METHODS AND COMPOSITIONS FOR TARGETED GENETIC MODIFICATIONS AND THEIR APPLICATION METHODS | 2015 |
|
RU2771532C2 |
