B4GALT1 OPTIONS AND THEIR APPLICATIONS Russian patent published in 2023 - IPC C12N9/10 C12N15/86 

FIELD: biotechnology.

SUBSTANCE: invention is related to an isolated polypeptide of the B4GALT1 variant containing a serine corresponding to position 352, a fusion protein containing it, and also to an isolated nucleic acid molecule encoding it. A method for modifying a cell using the above nucleic acid molecule, as well as a method for detecting a variant of the B4GALT1 nucleic acid molecule encoding serine at position corresponding to position 352 of the full-length/mature B4GALT1 polypeptide are also disclosed.

EFFECT: invention is effective for determining the susceptibility of a human subject to developing cardiovascular disease in the subject, as well as for treating a subject who is not a carrier of the B4GALT1 variant and has or is susceptible to developing cardiovascular disease in the subject.

36 cl, 20 dwg, 5 tbl, 11 ex