FIELD: biotechnology.
SUBSTANCE: invention is related to an isolated polypeptide of the B4GALT1 variant containing a serine corresponding to position 352, a fusion protein containing it, and also to an isolated nucleic acid molecule encoding it. A method for modifying a cell using the above nucleic acid molecule, as well as a method for detecting a variant of the B4GALT1 nucleic acid molecule encoding serine at position corresponding to position 352 of the full-length/mature B4GALT1 polypeptide are also disclosed.
EFFECT: invention is effective for determining the susceptibility of a human subject to developing cardiovascular disease in the subject, as well as for treating a subject who is not a carrier of the B4GALT1 variant and has or is susceptible to developing cardiovascular disease in the subject.
36 cl, 20 dwg, 5 tbl, 11 ex
Title |
Year |
Author |
Number |
TREATMENT OF OPHTHALMOLOGICAL PATHOLOGICAL CONDITIONS WITH ANGIOPOETIN-LIKE PROTEIN 7 (ANGPTL7) INHIBITORS |
2020 |
- Praveen, Kavita
- Schurmann, Claudia
- Gurski, Lauren
- Dostal, Tanya Teslovich
- Abecasis, Goncalo
- Baras, Aris
- Coppola, Giovanni
|
RU2812912C2 |
VARIANTS OF PROTEIN RELATED TO INTERLEUKIN-1 RECEPTOR AND CONTAINING SINGLE IMMUNOGLOBULIN DOMAIN (SIGIRR), AND USE THEREOF |
2018 |
- Gonzaga-Jauregui, Claudia G.
- Horowitz, Julie
|
RU2815068C2 |
THERAPEUTIC COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE |
2015 |
- Dejvidson Beverli L.
- Mas Montejs Alekhandro
|
RU2711147C2 |
NEW MINIMUM UTR SEQUENCES |
2017 |
- Plank Kristian
- Rudolf Karsten
- Anedzha Manish Kumar
- Vajss Lyudvig
|
RU2759737C2 |
TREATMENT OF RESPIRATORY DISORDERS USING ARACHIDONATE 15-LIPOXYGENASE (ALOX15) INHIBITORS |
2019 |
- Horowitz, Julie
- Baras, Aris
|
RU2799084C2 |
ARTIFICIAL MOLECULES OF NUCLEIC ACIDS FOR IMPROVED EXPRESSION OF PROTEINS AND PEPTIDES |
2013 |
|
RU2750261C2 |
ARTIFICIAL NUCLEIC ACID MOLECULES COMPRISING 5'TOP UTR |
2013 |
|
RU2660565C2 |
GENE THERAPY VECTORS FOR TREATING DANON'S DISEASE |
2020 |
- Keravala, Annahita
- Prabhakar, Raj
- Shah, Gaurav
- Wong, Roderick
- Yalamanchi, Naveen
- Pratumsuwan, Piratip
|
RU2822925C2 |
METHOD FOR RECOMBINANT POLYPEPTIDE PRODUCTION |
2012 |
- Tabuti Khisakhiro
- Sugiyama Tomoya
|
RU2628310C2 |
ARTIFICIAL NUCLEIC ACID MOLECULES FOR IMPROVED PROTEIN OR PEPTIDE EXPRESSION |
2013 |
|
RU2658490C2 |