COMPOUNDS FOR IMAGING OF TAU PROTEIN AGGREGATES Russian patent published in 2022 - IPC C07D471/14 A61K51/04 A61P25/00 A61P25/02 A61P25/08 A61P25/16 A61P25/28 A61P27/02 A61P27/06 C07B59/00 G01N33/60 

FIELD: medicine.

SUBSTANCE: invention relates to a compound of the formula (II), where R¹ is ¹⁸F; R² is H. The invention also relates to an intermediate compound of the formula (II), values of radicals of which are specified in the claims, the use of a not marked compound of the formula (II) as an analytical standard, as well as to a method for the production of a marked compound of the formula (II), a ki for the production of a radio pharmaceutical drug, a method for data collection for the diagnostics of a disorder associated with tau protein aggregates, for determination of predisposition to a disorder associated with tau protein aggregates, for monitoring of residual manifestation of a disorder in a patient suffering from a disorder associated with tau protein aggregates, and for prediction of a reaction of a patient suffering from a disorder associated with tau protein aggregates.

EFFECT: heterocyclic compounds are obtained, which can be used in selective detection of disorders and anomalies associated with tau protein aggregates, such as Alzheimer’s diseases and other tauopathies, using positron-emission tomography (PET).

21 cl, 5 dwg, 2 tbl, 34 ex