NEW COMPOUNDS FOR TREATING DISEASES, ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS Russian patent published in 2016 - IPC C07D209/14 C07D401/14 C07D471/04 C07D495/04 A61K31/437 A61P25/28 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to compounds of formula (I) possessing properties of aggregation of Aβ_1-42, pharmaceutical composition, based thereon, use thereof, method of treating using them, kit for detecting or diagnosing diseases, method of reducing deposits of β-amyloid plaques and method of maintaining or improving cognitive abilities. In general formula (I) A there are selected from group, consisting of (i), (ii), (iii), (iv), (v), (vi) and (viii), L₁ is selected from group, consisting of (a), B is selected from group, consisting of (ix), (x), (xi), (xii), (xiii), where R¹, R² and R³ are selected from group of hydrogen, halogen, CN, -CONR³⁰R³¹, -N(R³⁰)-C(O)-R³¹, alkyl, -O-alkyl, -C(O)O-alkyl, 6-membered heterocycle with 1-2 heteroatoms, selected from N and O, fluoroalkyl, where the heterocycloalkyl can be optionally substituted with acetyl or methyl group, or, if any of these groups R¹/R²/R³ are adjacent, they can be taken together and form 5-8-member ring, containing carbon atoms and optionally one or two heteroatoms, selected from O, S or N, and where 5-8-member ring can be substituted with NR²⁰R²¹ or -O-alkyl, where alkyl can be substituted with F, methoxy or SO₂Me; R^a is selected from hydrogen, alkyl; R^b is selected from hydrogen, halogen, CONR³⁰R³¹; R³⁰, R³¹, R²⁰ and R²¹ are selected from hydrogen, alkyl; X and Y are selected from CR^b and N; p equals to 0, 1 or 2.

EFFECT: compounds can be used for treating of group of violations and disorders, associated with amyloid protein, such as Alzheimer's disease, and diseases or conditions, associated with amyloid-like proteins, as well as for treating eye diseases, associated with pathological abnormalities/changes in visual system tissues.

36 cl, 12 dwg, 10 tbl, 219 ex

A-L₁-B (I)

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