NANOPARTICLES FOR USE FOR TREATMENT OF NEUROLOGICAL DISORDER Russian patent published in 2022 - IPC A61K33/24 A61K33/38 A61K33/242 A61K33/243 A61K33/244 A61K33/44 A61K33/08 A61K9/14 A61K9/16 A61P25/00 

FIELD: medicine.

SUBSTANCE: use of a nanoparticle or an aggregate of nanoparticles for the prevention or treatment of a neurological disease or at least one of its symptoms in a subject without affecting the nanoparticle or the aggregate of nanoparticles with an electric field or any other external source of activation is disclosed. Material of the nanoparticle or the aggregate of nanoparticles is selected from conductive material selected from Tl, Po, Ag, Pd, Ir, Pt, and/or Au and organic material having adjacent sp2-hybridized carbon centers in its structure; and insulating material selected from Al₂O₃, LaAlO₃, La₂O₃, SiO₂, SnO₂, Ta₂O₅, ReO₂, ZrO₂, HfO₂, and diamond-like carbon. In this case, i) a median size of a core of the nanoparticle or the aggregate of nanoparticles of a population is at least 30 nm, when material is conductive material, and ii) the core of the nanoparticle or the aggregate of nanoparticles is coated with biocompatible coating, iii) biocompatible coating providing a negative surface charge is selected from phosphate, dicarboxylic acid, succinic acid, or sulfate, and biocompatible coating providing a neutral surface charge is selected from an agent including a functional group selected from alcohol (R-OH), aldehyde (R-COH), ketone (R-CO-R), composite ester (R-COOR), acid (R-COOH), thiol (R-SH), saccharide, anhydride (RCOOOC-R), and pyrrole. The use of a composition including the above-described particles and/or aggregates of nanoparticles, and a pharmaceutically acceptable carrier for the prevention or treatment of a neurological disease or at least one of its symptoms in a subject are also disclosed.

EFFECT: group of inventions provides prevention or treatment of a neurological disease or at least one of its symptoms without affecting a nanoparticle or an aggregate of nanoparticles with an electric field.

6 cl, 21 dwg, 8 tbl, 13 ex