APPLICATION OF A DERIVATIVE OF 1,3,5-TRIAZINE-2,4-DIAMINE FOR INHIBITING THE REPLICATION OF BETACORONAVIRUSES, INCLUDING SARS-COV-2 Russian patent published in 2022 - IPC A61K31/53 A61P31/14 C07D251/54 C07D253/02 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to the field of pharmacology and medicine and is aimed at treating diseases caused by betacoronaviruses, including SARS-CoV-2. Described is an application of a derivative of 1,3,5-triazine-2,4-diamine by the general formula I, wherein R1 and R2 constitute a substituent selected from hydrogen; an alkyl (C1-C10) of an unbranched or branched structure; an aryl without substituents or substituted in positions 2,3,4,5,6; a hetaryl constituting a nitrogen-, and/or sulphur-, and/or oxygen-containing five- or six-membered heterocycle; R3 constitutes a substituent selected from hydrogen; or an alkyl (C1-C10) of an unbranched or branched structure; or an aryl without substituents or substituted in positions 2,3,4,5,6; or a hetaryl, wherein the hetaryl is a nitrogen-, and/or sulphur-, and/or oxygen-containing five- or a six-membered heterocycle; or an alkylNH, wherein the alkyl(C1-C10) is of an unbranched or branched structure; or an arylNH-, wherein the aryl is without substituents or is substituted in positions 2,3,4,5,6; or a hetarylNH-, wherein the hetaryl constitutes a nitrogen-, and/or sulphur-, and/or an oxygen-containing five- or six-membered heterocycle; or pyrrolidine-1-yl, piperidine-1-yl, morpholine-4-yl-, piperazine-1-yl-, homopiperazine-1-yl-, tetrahydroquinoline-1-yl-, tetrahydroisoquinoline-2-yl-, hexamethyleneiminyl; or R4CH₂-, wherein R4 is selected from an alkyl (C1-C10) of an unbranched or branched structure; an aryl without substituents or substituted in positions 2,3,4,5,6; a hetaryl, wherein the hetaryl constitutes a nitrogen-, and/or sulphur-, and/or oxygen-containing five- or six-membered heterocycle; pyrrolidine-1-yl, piperidine-1-yl, morpholine-4-yl-, piperazine-1-yl-, homopiperazine-1-yl-, tetrahydroquinoline-1-yl-, tetrahydroisoquinoline-2-yl, hexamethyleneiminyl for suppressing the replication of betacoronavirus.

EFFECT: ensured effective suppression of the replication of betacoronaviruses, including SARA-CoV-2, at low values of the effective concentration of EC₅₀, low cytotoxicity, and high value of selectivity index.

5 cl, 1 tbl, 7 ex