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2 784 940

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IPC

C07D487/22(2006-01-01)

A61K31/409(2006-01-01)

A61K31/4439(2006-01-01)

A61P31/14(2006-01-01)

(21) (22)

Application

2022121270, 2022-08-03

(24)

Start date

2022-08-03

(22)

Actual filing date

2022-08-03

(45)

Published

2022-12-01

(72)

Inventor

Syrbu Sergej AleksandrovichSemejkin Aleksandr StanislavovichLebedeva Natalya ShamilevnaGubarev Yurij AleksandrovichYurina Elena Sergeevna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Khimii Rastvorov Im. G.A. Krestova Rossijskoj Akademii Nauk Ran)Federalnoe Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Khimiko-Tekhnologicheskij Universitet"

5,15-BIS(4'-BIS-L-TYROSINYLAMIDOPHENYL)-10,20-BIS(N-METHYLPYRIDINIUM-3'-YL)PORPHIN DIOODIDE, SHOWING THE PROPERTY OF BINDING SARS-COV-2 VIRUS S-PROTEIN Russian patent published in 2022 - IPC C07D487/22 A61K31/409 A61K31/4439 A61P31/14

Abstract RU 2784940 C1

FIELD: organic chemistry.

SUBSTANCE: invention relates to organic chemistry, namely to 5,15-bis(4'-bis-L-tyrosinylamidophenyl)-10,20-bis(N-methylpyridinium-3'-yl)porphine diiodide.

EFFECT: a water-soluble porphyrin was obtained, which has two peripheral extended hydrophobic substituents that bind to the S2 subunit of the SARS-CoV-2 S-protein, the tyrazyl fragments of which will provide additional stability to the complex due to the formation of several hydrogen bonds with the amino acid residues of the polypeptide chain of the S2 unit.

1 cl, 5 dwg, 1 tbl, 1 ex

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RU 2 784 940 C1

Authors

Syrbu Sergej Aleksandrovich

Semejkin Aleksandr Stanislavovich

Lebedeva Natalya Shamilevna

Gubarev Yurij Aleksandrovich

Yurina Elena Sergeevna

Dates

2022-12-01—Published

2022-08-03—Filed