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2 780 515

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(51)

IPC

C07C231/04(2006-01-01)

C07C235/80(2006-01-01)

(21) (22)

Application

2021139355, 2021-12-28

(24)

Start date

2021-12-28

(22)

Actual filing date

2021-12-28

(45)

Published

2022-09-26

(72)

Inventor

Akhmetova Vnira RakhimovnaSmirnov Oleg Vladimirovich

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Nauchnoe Uchrezhdenie Ufimskii Federalnyi Issledovatelskii Tsentr Rossiiskoi Akademii Nauk

METHOD FOR THE PREPARATION OF AMIDES OF 2-ACYL-3-OXOBUTANOIC ACID Russian patent published in 2022 - IPC C07C231/04 C07C235/80

Abstract RU 2780515 C1

FIELD: organic chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to a method for producing amides of 2-acyl-3-oxo-butanoic acid of the general formula (1), where X = n-C₃H₇, n-C₄H₉, n-C₆H₁₃, cyclo-C₅H₉, cyclo-C₆H₁₁. The method consists in the interaction of sodium bicarbonate with acetylacetone and primary amines in the presence of a nickel (II) acetylacetonate catalyst at a molar ratio of NaHCO₃: acac: amine: Ni(acac)₂=1:2:2:0.03 in isopropyl alcohol at a temperature of 80°C for 2 hours.

EFFECT: method makes it possible to reduce the reaction time and obtain a product with a high yield.

1 cl, 1 tbl, 5 ex

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RU 2 780 515 C1

Authors

Akhmetova Vnira Rakhimovna

Smirnov Oleg Vladimirovich

Dates

2022-09-26—Published

2021-12-28—Filed