PYRIMIDINE COMPOUNDS CONTAINING ACID GROUPS Russian patent published in 2022 - IPC C07D239/49 C07D403/10 C07D403/12 C07F5/02 C07F9/6512 A61K31/505 A61K31/506 A61K31/675 A61K31/69 A61P31/12 A61P35/00 

FIELD: medicine.

SUBSTANCE: present invention relates to a compound having a structure of the Formula (1) or to its pharmaceutically acceptable salt, having immunomodulating properties, which act through TLR, and which are useful in the treatment of viral infections and cancer diseases.

,

where R^1a is selected from a group consisting of H, C₁-C₄ alkyl, and A, where alkyl is optionally substituted with -COOH, -SO₂CH₃, -SCH₃, -OCH₃, or A; R^1b is C₂-C₅ alkyl; X is C₁-C₄ alkyl, where alkyl is optionally substituted with A or -OH; L¹ is selected from a group consisting of a bond, -CH₂-, -O- and -CH₂CH₂-; Y is selected from a group consisting of C₁-C₃ alkyl and C₆ aryl, where C₆ aryl is optionally substituted with 1-5 substituents, which are independently selected from A, C₁-C₃ alkyl, and C₁-C₃ alkoxy; A is selected from a group consisting of , , , , and ; L² is selected from a group consisting of a bond, -(CH₂)_n-, -C(O)NH(CH₂)_n-, , and ; m is an integer from zero to four; n is an integer from one to four; where the compound is substituted with at least one A. In this case, following conditions are satisfied: when X is -CH₃, L¹ is -CH₂-, Y is C₆ aryl substituted with A, and L² is -CH₂-, then A is not -L²-COOH, except for cases, when R^1a contains -COOH or -SO₂CH₃; and, when X is -CH₃, L¹ is -CH₂-, Y is C₆ aryl substituted with A, L² is -CH₂-, and A is , then A and L¹ are not in a pair position relatively to each other.

EFFECT: obtaining a compound for the treatment of viral infections and cancer diseases.

55 cl, 1 tbl, 53 ex