FIELD: medicine.
SUBSTANCE: invention relates to the field of medicine, namely to a method for the differential diagnosis of the formation of the mucous membrane of the lip, and can be used in the differential diagnosis of inflammatory diseases and malignant neoplasms of the oral cavity in the conditions of dental, oncological and surgical medical institutions. method involves taking oral fluid from a patient and performing enzyme immunoassay on a plate based on monoclonal antibodies, followed by analysis of research results, matrix metalloproteinase 9/matrix metalloproteinase 9 (MMP 9/MMP 9) and tissue inhibitor of metalloproteinase 2/tissue inhibitor are selected as biomarkers. of metalloproteinase 2 (TIMP 2/TIMP 2) and determination of their quantitative content in the patient's oral fluid. If the content in the oral fluid of matrix metalloproteinase 9/matrix metalloproteinase 9 (MMP 9/MMP 9) is determined in the amount of 176.93-204.07 ng/ml and tissue inhibitor of metalloproteinase 2/tissue inhibitor of metalloproteinase 2 (TIMP 2/TIMP 2) in the amount of 25.29-33.59 ng/ml, then inflammation of the mucous membrane of the lip is diagnosed. If the content in the patient's oral fluid of matrix metalloproteinase 9/matrix metalloproteinase 9 (MMP 9/MMP 9) is determined in the amount of 2498.78-2827.22 ng/ml and tissue inhibitor of metalloproteinase 2/tissue inhibitor of metalloproteinase 2 (TIMP 2/TIMP 2 ) in the amount of 58.52-66.28 ng/ml, then squamous cell carcinoma of the mucous membrane of the lip is diagnosed when determining dental health, then, based on the results of determining the content of biomarkers in the oral fluid of the patient, the tactics of treating the patient are predicted.
EFFECT: invention provides for achieving a significant increase in the diagnostic accuracy of differential diagnosis of inflammation and squamous cell carcinoma of the mucous membrane of the lip on the day of the patient's visit, a significant increase in the sensitivity of differential express diagnostics, achieving a high probability of detecting inflammation and squamous cell carcinoma in the patient's body both in the early stages of the disease and at later, as well as a significant simplification of the preparation of the patient within a certain time frame for the collection and storage of diagnostic material.
3 cl, 2 ex
