FIELD: biotechnology and medicine.
SUBSTANCE: invention relates to biotechnology and medicine, namely to oncohematology for predicting the risk of recurrence of acute myeloid leukemia in children after allogeneic transplantation of hematopoietic stem cells. A set of oligodeoxyribonucleotide primers and fluorescently labeled DNA probes is developed to determine the expression of the CD34, FAM30A, SOCS2, GPR56, DNMT3B, SPINK2 genes, followed by determination of the level of relative expression relative to the ABL1 reference gene. Together, the level of expression of the above genes can be used as a predictor of the development of early recurrence of AML in children after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
EFFECT: invention can be used to detect the level of expression of genes characteristic of leukemic stem cells (LSCs) of acute myeloid leukemia (AML) in children by real-time polymerase chain reaction (RT-PCR) before allogeneic bone marrow transplantation in order to predict the risk of early post-transplant recurrence.
1 cl, 1 tbl, 1 dwg
Title |
Year |
Author |
Number |
TEST SYSTEM AND METHOD FOR DETECTING A, B, D MUTATIONS OF NPM1 GENE FOR QUANTITATIVE DETERMINATION OF MINIMAL RESIDUAL DISEASE |
2023 |
- Sidorova Iuliia Vladimirovna
- Severina Nataliia Aleksandrovna
- Sudarikov Andrei Borisovich
|
RU2830545C1 |
METHOD FOR DETECTION OF STRUCTURAL REARRANGEMENTS OF TUMOR CELLS (CHEMERIC GENES) GENOME, DETERMINING SELECTION OF THERAPY AND PREDICTION IN ACUTE LEUKOSIS IN CHILDREN, USING OT-PCR AND SUBSEQUENT HYBRIDIZATION WITH OLIGONUCLEOTIDE BIOLOGICAL MICROCHIP (BIOCHIP) |
2016 |
- Ikonnikova Anna Yurevna
- Fesenko Denis Olegovich
- Karateeva Anna Vladimirovna
- Zasedatelev Aleksandr Sergeevich
- Nasedkina Tatyana Vasilevna
|
RU2639513C1 |
METHOD OF ASSESSING MINIMAL RESIDUAL DISEASE (MRD) BY MULTICOLOR FLOW CYTOMETRY IN PATIENTS WITH ACUTE MYELOID LEUKEMIA (AML) IN THE POST-INDUCTION PHASE OF TREATMENT |
2022 |
- Galtseva Irina Vladimirovna
- Lukianova Irina Anatolevna
- Davydova Iuliia Olegovna
- Kapranov Nikolai Mikhailovich
- Nikiforova Kseniia Aleksandrovna
- Kulikov Sergei Mikhailovich
- Parovichnikova Elena Nikolaevna
|
RU2802131C1 |
METHOD FOR DIAGNOSING ACUTE LEUKEMIA AND KITS FOR ITS IMPLEMENTATION |
2021 |
- Olkhovskij Igor Alekseevich
- Gorbenko Aleksej Sergeevich
- Stolyar Marina Aleksandrovna
- Komarovskij Yurij Yurevich
- Tyumentseva Anna Vladimirovna
|
RU2806591C2 |
RECOMBINANT PLASMID pAL2-T-WBMAG DNA, USED FOR CREATION OF DNA-CALIBRATORS AT THERAPY EFFICIENCY ASSESSMENT FOR PATIENTS WITH ACUTE MYELOID LEUKEMIA |
2017 |
- Potter Alisa Yanovna
- Barkhatov Ildar Munerovich
- Shakirova Alena Igorevna
- Chukhlovin Aleksej Borisovich
- Afanasev Boris Vladimirovich
|
RU2642315C1 |
METHOD OF POLYMORPHIC MARKERS ANALYSIS IN THE GENES OF METABOLISM OF MEDICINAL PREPARATIONS AND THE GENES OF IMMUNE RESPONSE IN THE ACUTE LEUCOSISES THERAPY IN CHILDREN |
2016 |
- Avdonina Mariya Alekseevna
- Fesenko Denis Olegovich
- Zasedatelev Aleksandr Sergeevich
- Nasedkina Tatyana Vasilevna
|
RU2643333C1 |
RECOMBINANT PLASMID DNA PAL2-T-EXP, USED TO CREATE DNA CALIBRATORS IN EVALUATING THE EFFECTIVENESS OF THERAPY IN PATIENTS WITH ACUTE MYELOID LEUKEMIA |
2017 |
- Potter Alisa Yanovna
- Barkhatov Ildar Munerovich
- Izmajlova Ekaterina Andreevna
|
RU2670543C1 |
ANTI-IL1RAP ANTIBODIES AND THEIR USE FOR TREATING HUMAN |
2012 |
- Fioretos Toas
- Jeros Markus
|
RU2597831C2 |
T CELLS RE-TARGETED WITH RESPECT TO CD123-SPECIFIC CHIMERIC ANTIGEN RECEPTOR, AND METHODS FOR USE THEREOF |
2014 |
- Formen Stiven
- Mardajros Armen
|
RU2711114C2 |
BISPECIFIC DIABODIES CD123 X CD3 FOR TREATING HAEMATOLOGICAL MALIGNANCIES |
2019 |
- Devidson, Yan Kennet
- Cherch, Sara
- Rutella, Serdzhio
|
RU2837616C2 |