24-DIBROM-4-OXO-2-CYANO-3,23-DINOLUP-28-OIC ACID METHYL ETER WITH CYTOTOXIC ACTIVITY Russian patent published in 2022 - IPC C07J9/00 A61P35/00 A61K31/575 

Abstract RU 2784317 C1

FIELD: chemistry.

SUBSTANCE: invention relates to the field of chemistry of natural compounds of the class of 3,4-secolupane triterpenoids - methyl ester of 24,24-dibromo-4-oxo-2-cyano-3,23-dinorlupan-28-oic acid, which exhibits cytotoxic activity, in including cancer cell lines MCF-7, HCT 116, RD TE 32, MS, A549, PC-3, HepG2, HBL-100, HBL-100/Dox.

EFFECT: providing 3,4-seco-lupane triterpenoids, which contain dibromo and nitrile groups in the cleaved A ring and have cytotoxic properties.

2 cl, 2 tbl, 2 ex

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RU 2 784 317 C1

Authors

Tolmacheva Irina Anatolevna

Nazarov Mikhail Andreevich

Gagarskikh Olga Nikolaevna

Grishko Viktoriya Viktorovna

Dates

2022-11-23Published

2022-06-06Filed