24-DIBROM-4-OXO-2-CYANO-3,23-DINOLUP-28-OIC ACID METHYL ETER WITH CYTOTOXIC ACTIVITY Russian patent published in 2022 - IPC C07J9/00 A61P35/00 A61K31/575 

Abstract RU 2784317 C1

FIELD: chemistry.

SUBSTANCE: invention relates to the field of chemistry of natural compounds of the class of 3,4-secolupane triterpenoids - methyl ester of 24,24-dibromo-4-oxo-2-cyano-3,23-dinorlupan-28-oic acid, which exhibits cytotoxic activity, in including cancer cell lines MCF-7, HCT 116, RD TE 32, MS, A549, PC-3, HepG2, HBL-100, HBL-100/Dox.

EFFECT: providing 3,4-seco-lupane triterpenoids, which contain dibromo and nitrile groups in the cleaved A ring and have cytotoxic properties.

2 cl, 2 tbl, 2 ex

Similar patents RU2784317C1

Title Year Author Number
METHYL ESTERS 3-METHYL-3-OXO-1-CYANO-2,3-SECO-2-NORLUP-20(29)-ENE-30-AL-28 AND 3-BROMETHYLENE-3-OXO-1-CYANO -2,3-SECO-2-NORLUP-20(29)-ENE-30-AL-28 ACIDS WHICH EXHIBIT CYTOTOXIC ACTIVITY 2016
  • Konysheva Anastasiya Vladimirovna
  • Nebogatikov Vladimir Olegovich
  • Tolmacheva Irina Anatolevna
  • Grishko Viktoriya Viktorovna
  • Rybalkina Ekaterina Yurevna
  • Karamysheva Aida Fuadovna
RU2632002C1
CYTOTOXIC AND ANTIVIRAL ACTIVITY OF 3-ACYLOXYMETHYL-3-OXO-1-CYANO-2,3-SECO-2-NOR-TRITERPENOIDS 2018
  • Krajnova Gulnaz Faizovna
  • Eroshenko Darya Vladimirovna
  • Grishko Viktoriya Viktorovna
RU2686100C1
CYTOTOXIC AND ANTI-VIRAL ACTIVITY OF 3-ACYLOXIMETHYL-3-OXO-1-CYANO-2,3-SECO-2-NOR-TRITERPENOIDES 2018
  • Krajnova Gulnaz Faizovna
  • Savinova Olga Vladimirovna
  • Eroshenko Darya Vladimirovna
  • Boreko Evgenij Ivanovich
  • Eremin Vladimir Fedorovich
  • Grishko Viktoriya Viktorovna
RU2682669C1
PHOSPHONIUM SALTS BASED ON BETULINIC ACID GLYCOSIDES WITH ANTITUMOR ACTIVITY 2022
  • Tsepaeva Olga Viktorovna
  • Salikhova Taliia Ilshatovna
  • Ishkaeva Rezeda Anasovna
  • Nemtarev Andrei Vladimirovich
  • Abdullin Timur Ildarovich
  • Laikov Aleksandr Vladimirovich
  • Idrisova Leisan Radikovna
  • Mironov Vladimir Fedorovich
RU2803739C1
N-[3-OXOLUP-20(29)-ENE-28-OIL]-2,2,6,6-TETRAMETHYLPIPERIDINE-4-YLAMINE WITH CYTOTOXIC ACTIVITY IN RESPECT OF HUMAN TUMOUR CELLS 2017
  • Pokrovskij Andrej Georgievich
  • Pokrovskij Mikhail Andreevich
  • Cheresiz Sergej Vladimirovich
  • Shults Elvira Eduardovna
  • Volkova Anna Nikolaevna
  • Petrenko Natalya Ivanovna
RU2641900C1
TRITERPENOIDS WITH EH-NITRILE FRAGMENT IN A-PENTACYCLE 2012
  • Grishko Viktorija Viktorovna
  • Tolmacheva Irina Anatol'Evna
  • Galajko Natal'Ja Vladimirovna
  • Boreko Evgenij Ivanovich
  • Eremin Vladimir Fedorovich
  • Savinova Ol'Ga Vladimirovna
  • Kucherov Igor' Ivanovich
RU2496785C1
2,3-SECO-DERIVATIVES OF BETULONIC ACID 2009
  • Tolmacheva Irina Anatol'Evna
  • Grishko Viktorija Viktorovna
  • Boreko Evgenij Ivanovich
  • Savinova Ol'Ga Vladimirovna
  • Pavlova Natal'Ja Il'Inichna
RU2410390C1
A-SECO-TRITERPENOIDS WITH METHYLKETONE FRAGMENT 2013
  • Tolmacheva Irina Anatol'Evna
  • Grishko Viktorija Viktorovna
  • Pereslavtseva Anastasija Vladimirovna
  • Eremin Vladimir Fedorovich
  • Boreko Evgenij Ivanovich
  • Kucherov Igor' Ivanovich
  • Savinova Ol'Ga Vladimirovna
RU2537840C1
HYBRID DERIVATIVE OF LUPANE TRITERPENOID AND GALLIC ACID CONTAINING A 1,2,3-TRIAZOLE LINKER WITH ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY 2023
  • Popov Sergei Aleksandrovich
  • Chzhiven Tsi
  • Shults Elvira Eduardovna
  • Pu Tsziun Se
  • Chenchzhan Van
RU2811236C1
16-(1,2,4-OXADIAZOL-3-YL)-15,16-EPOXILABDANOIDS POSSESSING CYTOTOXIC ACTIVITY ON HUMAN TUMOUR CELLS 2011
  • Shul'Ts Ehl'Vira Ehduardovna
  • Kharitonov Jurij Viktorovich
  • Pokrovskij Mikhail Andreevich
  • Pokrovskij Andrej Georgievich
  • Tolstikov Genrikh Aleksandrovich
RU2473550C1

RU 2 784 317 C1

Authors

Tolmacheva Irina Anatolevna

Nazarov Mikhail Andreevich

Gagarskikh Olga Nikolaevna

Grishko Viktoriya Viktorovna

Dates

2022-11-23Published

2022-06-06Filed