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2 473 550

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IPC

C07D413/04(2006-01-01)

A61K31/41(2006-01-01)

A61K31/341(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2011135583/04, 2011-08-25

(24)

Start date

2011-08-25

(22)

Actual filing date

2011-08-25

(45)

Published

2013-01-27

(72)

Inventor

Shul'Ts Ehl'Vira EhduardovnaKharitonov Jurij ViktorovichPokrovskij Mikhail AndreevichPokrovskij Andrej GeorgievichTolstikov Genrikh Aleksandrovich

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Novosibirskij Institut Organicheskoj Khimii Im. N.N. Vorozhtsova Sibirskogo Otdelenija Ran So Ran)

16-(1,2,4-OXADIAZOL-3-YL)-15,16-EPOXILABDANOIDS POSSESSING CYTOTOXIC ACTIVITY ON HUMAN TUMOUR CELLS Russian patent published in 2013 - IPC C07D413/04 A61K31/41 A61K31/341 A61P35/00

Abstract RU 2473550 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to organic chemistry, specifically to 16-(1,2,4-oxadiazol-3-yl)-15,16-epoxilabdanoids of formula

wherein R=Me(Ia), Ph(1b), CH₂Cl(lc) possessing an ability to inhibit human tumour cell growth. The compounds are produced of lambertianic acid contained in Siberian cedar gum and fir needles.

EFFECT: there are produced new compounds which possess considerable cytotoxic activity on human tumour cells.

1 cl, 1 tbl, 4 ex

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RU 2 473 550 C1

Authors

Shul'Ts Ehl'Vira Ehduardovna

Kharitonov Jurij Viktorovich

Pokrovskij Mikhail Andreevich

Pokrovskij Andrej Georgievich

Tolstikov Genrikh Aleksandrovich

Dates

2013-01-27—Published

2011-08-25—Filed