METHOD FOR PREDICTING THE THREAT OF TERMINATED PREGNANCY IN THE SECOND TRIMESTER IN THE FORM OF THREATENED LATE MISCARRIAGE AND THREATENED PREMATURE BIRTH IN WOMEN WITH IVF PREGNANCY Russian patent published in 2022 - IPC G01N33/577 G01N33/49 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely, to obstetrics and gynaecology. The content of vascular-endothelial growth factor A — VEGF-A and trophoblastic β-1-glycoprotein — TBG is determined in the peripheral venous blood of women with IVF pregnancy at the gestational age of 11 to 14 weeks, followed by calculating the prognostic index D according to the formula: D = 4,016 - 0.0058 × X1 - 0.0001 × X2, wherein X1 is the content of VEGF-A (pg/ml); X2 is the content of TBG (ng/ml); 4,016 is a constant. If D is less than 0, a threat of terminated pregnancy in the second trimester in the form of threatened late miscarriage and threatened premature birth is predicted. If D is greater than 0, the absence of a threat of terminated pregnancy in the second trimester in the form of threatened late miscarriage and threatened premature birth is predicted.

EFFECT: possibility of providing a personalised approach to the treatment of women with IVF pregnancy and providing timely preventive and therapeutic measures for the purpose of prolonging pregnancy and improving the perinatal outcomes.

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