FIELD: medicine; pharmaceutics.
SUBSTANCE: invention relates to the field of medicine and pharmaceutics; it can be used for the treatment of Alzheimer’s disease. A therapeutic agent for the treatment of Alzheimer’s disease is a combination of (S)-7-(20methoxy-3,5-dimethylpyridine-4-yl)-1-(tetrahydrofuran-3-yl)-1H-pyrazolo[4,3-c]quinoline-4(5H)-one, which is represented by the formula (I)
,
or its pharmaceutically acceptable salt and memantine, which is represented by the formula (II) 
,
or its pharmaceutically acceptable salt. A method for the treatment of Alzheimer’s disease and the use of the specified therapeutic agent for the treatment of Alzheimer’s disease are also proposed.
EFFECT: invention provides an enhancing effect of a compound (I) relatively to a cognitive function in case of being used in a combination with memantine with a reduced dose of compounds.
19 cl, 4 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| THERAPEUTIC FOR THE TREATMENT OF LEWY BODY DISEASE CONTAINING PYRAZOLOQUINOLINE DERIVATIVE | 2018 |
|
RU2802212C2 |
| PYRIDINYLPYRAZOLOQUINOLINE COMPOUNDS | 2014 |
|
RU2655172C2 |
| SALT OF PYRAZOLOQUINOLINE DERIVATIVE AND CRYSTAL THEREOF | 2014 |
|
RU2655171C2 |
| PIRAZOLOQINOLINE DERIVATIVE | 2012 |
|
RU2605096C2 |
| ORGANIC COMPOUNDS | 2015 |
|
RU2702732C1 |
| SUBSTITUTED 2-AMINO-3-SULFONYL-TETRAHYDRO-PYRAZOLO[1,5-a]PYRIDO-PYRIMIDINES-ANTAGONISTS OF SEROTONIN 5-HT RECEPTORS, METHODS OF PRODUCING AND USING SAID COMPOUNDS | 2008 |
|
RU2384581C2 |
| ORGANIC COMPOUNDS | 2015 |
|
RU2709786C2 |
| AGONISTS OF 5-HT4-RECEPTORS FOR TREATING DEMENTIA | 2011 |
|
RU2569733C2 |
| (3-ARYLSULPHONYL QUINOLIN-8-YL-DIALKYL-AMINES - SELECTIVE SEROTONIN 5-HT RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF | 2012 |
|
RU2500672C1 |
| SUBSTITUTED PYRAZOLOAZEPINE-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | 2016 |
|
RU2762279C2 |
