FIELD: chemistry.
SUBSTANCE: invention relates to novel (3-arylsulphonyl quinolin-8-yl-dialkyl-amines of general formula 1 and pharmaceutically acceptable salts thereof, which are selective antagonists of serotonin 5-HT6 receptors. The compounds can be used as an active ingredient in pharmaceutical compositions and medicinal agents for treating diseases of the central nervous system, pathogenesis of which is associated with 5-HT6 receptors. In particular, the compounds can be used in case of neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease, in anxiety or cognitive disorders and for enhancing mental capabilities. In general formula 1 
, Ar is phenyl, optionally substituted in position 3 with a halogen atom, or naphthyl, R1 and R2 are an unsubstituted methyl or ethyl.
EFFECT: improved method.
10 cl, 9 dwg, 2 tbl, 8 ex
| Title |
Year |
Author |
Number |
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2008 |
- Ivashchenko Aleksandr Vasil'Evich
- Savchuk Nikolaj Filippovich
- Ivashchenko Andrej Aleksandrovich
|
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2008 |
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2008 |
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2008 |
- Ivashchenko Aleksandr Vasil'Evich
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2008 |
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2008 |
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|
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2008 |
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|
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- Ivashchenko Aleksandr Vasil'Evich
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|
RU2421456C1 |
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2008 |
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- Kisil' Volodimir Mikhajlovich
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|
RU2384581C2 |
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2008 |
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RU2399621C2 |
