CRYSTAL FORM OF COMPOUND OF 1H-IMIDAZO[4,5-b]PYRIDINE-2(3H)-ONE AND ITS PRODUCTION METHOD Russian patent published in 2022 - IPC C07D471/04 A61K31/519 A61P29/00 A61P37/00 

FIELD: medicine.

SUBSTANCE: invention relates to a crystal Form A of a compound 1, where the crystal Form A is characterized by X-ray powder diffractogram having characteristic diffraction peaks at following angles 2θ: 10.69±0.2°, 12.31±0.2°, 13.45±0.2°, 14.10±0.2°, 14.62±0.2°, 19.07±0.2°, 20.33±0.2°, 21.79±0.2°. The crystal Form A of the compound 1 is obtained by addition of the compound 1 to an alcohol solvent, a ketone solvent, a mixed solvent consisting of the alcohol solvent and water, a mixed solvent consisting of the ketone solvent and water; the alcohol solvent is selected from a group consisting of methanol, ethanol; the ketone solvent is selected from a group consisting of acetone, and heating for dissolution, and then cooling for crystallization to obtain the crystal Form A. At the same time, the mixed solvent consisting of the alcohol solvent and water consists of a mixed solvent consisting of ethanol and water.

EFFECT: crystal Form A of a compound of 1H-imidazo[4,5-b]pyridine-2(3H)-one (1), having good stability, intended for the use in the production of a drug for the treatment of a disease related to PDE4 receptor.

10 cl, 4 dwg, 10 tbl, 9 ex