FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to an animal other than human for expression of human transthyretin (hereinafter – TTR) protein or chimeric TTR protein, including genetically modified endogenous Ttr locus including a human TTR sequence including both a TTR-encoding sequence and a non-encoding sequence, its cell, as well as to a method for its production. A nucleic acid molecule encoding the above-mentioned antibody or its fragment, as well as a cell and a vector containing it are also disclosed. The invention also relates to a method for the production of an antibody against Abeta or its antigen-binding fragment.
EFFECT: invention is effective for optimization of activity of a human TTR-targeting reagent in vivo, as well as for assessment of activity of the human TTR-targeting reagent in vivo.
26 cl, 20 dwg, 11 tbl, 4 ex
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