FIELD: biochemistry.
SUBSTANCE: invention relates to a rodent for the expression of human protein ANGPTL8, the genome of which contains a constructed gene of angiopoietin-like protein 8 (Angptl8) in the endogenous locus Angptl8, as well as to its cell, tissue and embryo. Also disclosed is a method of producing a rodent expressing a human ANGPTL8 polypeptide from an endogenous gene Angptl8. Invention also relates to a method of evaluating the efficacy of a medicament specifically affecting human ANGPTL8, as well as to a method for assessing the pharmacokinetic properties of a medicament specifically affecting human ANGPTL8, involving use of said rodent.
EFFECT: invention is effective for identifying and developing new therapeutic agents which can be used for treating cardiovascular diseases, disorders or conditions.
20 cl, 9 dwg, 1 tbl, 4 ex
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| GENETICALLY MODIFIED NON-HUMAN ANIMALS EXPRESSING HUMAN EPO | 2015 |
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| RODENTS CHARACTERIZED BY THE HUMANIZED TMPRSS GENE | 2017 |
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| NON-HUMAN ANIMALS CONTAINING THE HUMANIZED ASGR1 LOCUS | 2018 |
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