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2 785 543

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IPC

C07D498/22(2006-01-01)

A61K31/4985(2006-01-01)

A61K31/4162(2006-01-01)

A61P35/00(2006-01-01)

A61P35/02(2006-01-01)

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Application

2021123116, 2021-07-30

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Start date

2021-07-30

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Actual filing date

2021-07-30

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Published

2022-12-08

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Inventor

Ibragimov Askhat GabdrakhmanovichRakhimova Elena BorisovnaKirsanov Viktor YurevichDzhemileva Lilya UseinovnaDyakonov Vladimir Anatolevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Ufimskij Federalnyj Issledovatelskij Tsentr Rossijskoj Akademii Nauk

2,8-BIS-(5-METHYLISOXAZOL-3-YL OR 1,5-DIMETHYL-3-OXO-2-PHENYL-1,2-DIHYDRO-3H-PYRAZOL-4-YL)-2,3,8, 9,12c,12d-HEXAHYDRO-1H,7H-5,11-DIOXA-2,3a.4,6,6b8,9a,10,12,12b-DECAAZADICYCLOPENTA[e,l]PYRENES, METHOD FOR THEIR PRODUCTION AND APPLICATION IN AS A PRODUCT WITH CYTOTOXIC ACTIVITY Russian patent published in 2022 - IPC C07D498/22 A61K31/4985 A61K31/4162 A61P35/00 A61P35/02

Abstract RU 2785543 C1

FIELD: chemistry.

SUBSTANCE: invention relates to 2,8-bis-(5-methylisoxazol-3-yl or 1,5-dimethyl-3-oxo-2-phenyl-1,2-dihydro-3H-pyrazol-4-yl)-2,3 ,8,9,12c,12d-hexahydro-1H,7H-5,11-dioxa-2,3a,4,6,6b,8,9a,10,12,12b-decaazadicyclopenta[e,l]pyrenes of general formula (one):

Also described is a method for obtaining the above compound, which consists in the interaction of hetarylamine of the general formula Het-NH₂ (where Het = 5-methylisoxazol-3-yl or 1,5-dimethyl-3-oxo-2-phenyl-1,2-dihydro-3H -pyrazol-4-yl) with formaldehyde and 1,4,5,8-tetraazadifurazano[3,4-c][3,4-h]decalin in the presence of a conc. HCl at the molar ratio of hetarylamine : formaldehyde : 1,4,5,8-tetraazadifurazano[3,4-c][3,4-h]decalin : HCl=2:4:1:(0.03-0.07) in CH₃OH-DMSO at a temperature of 20°C and atmospheric pressure for 2.5-3.5 hours.

EFFECT: resulting heterocycles exhibit cytotoxic activity and can be used as candidate compounds for the development of drugs with antitumor activity and antiproliferative activity.

3 cl, 2 tbl, 6 ex

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RU 2 785 543 C1

Authors

Ibragimov Askhat Gabdrakhmanovich

Rakhimova Elena Borisovna

Kirsanov Viktor Yurevich

Dzhemileva Lilya Useinovna

Dyakonov Vladimir Anatolevich

Dates

2022-12-08—Published

2021-07-30—Filed