FIELD: biotechnology.
SUBSTANCE: group of inventions is described, including a conjugate of an anti-hB7-H3 antibody and a drug for inhibiting Bcl-xL (options). In one of implementations, the antibody is IgG1 antibody against hB7-H3, containing a variable region of a heavy chain, containing CDR3 domain of the heavy chain, containing an amino acid sequence SEQ ID NO:35, CDR2 domain of the heavy chain, containing an amino acid sequence SEQ ID NO:34, and CDR1 domain of the heavy chain, containing an amino acid sequence SEQ ID NO:33; and a variable region of a light chain containing CDR3 domain of the light chain, containing an amino acid sequence SEQ ID NO:39, CDR2 domain of the light chain, containing an amino acid sequence SEQ ID NO:38, and CDR1 domain of the light chain, containing an amino acid sequence SEQ ID NO:37.
EFFECT: invention expands the arsenal of means for inhibiting Bcl-xL.
3 cl, 5 dwg, 29 tbl, 22 ex
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