METHOD FOR RECOGNISING THE STRUCTURE OF BLOOD AND BONE MARROW BLAST NUCLEI Russian patent published in 2022 - IPC G16H10/00 G06T7/00 

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine and can be used to recognise the structure of blood and bone marrow blast nuclei using light microscopy in combination with computer data processing. According to the invention, a colour image of blood and/or bone marrow smears is obtained using a computer analyser; leukocytes are isolated in the image, and a binary image thereof is obtained; a void-filling procedure is performed on the binary image of leukocytes by incremental scanning; the spatial brightness distribution of pixels of the image is measured, and the value of textural attributes characterising the nuclear structure is determined for the representations of colour models of leukocytes; based on the textural attributes, a matrix of numerical textural attributes of the nuclear structure is formed, wherein the columns contain the values of textural attributes and the rows contain the leukocyte images used to recognise the structure of blast nuclei. The values of textural attributes characterising the structure of leukocyte nucleus are determined for four directions of adjacency, wherein the textural attribute "local uniformity" for the red component of the colour image is determined using adjacency distances of eleven pixels, the textural attribute "moment of inertia" for the red component of the colour image is determined by calculating for the adjacency distance of two pixels, the textural attribute "moment of inertia" for the blue component of the colour image is determined using adjacency distances of seven pixels, the textural sign "entropy" for the blue component of the colour image is determined using adjacency distances of six pixels, and the textural attribute "energy" for the blue component of the colour image is determined using adjacency distances of six pixels.

EFFECT: increased reliability of diagnosing due to the use of attributes allowing for high informative value.

6 cl, 5 dwg