COMPOSITIONS AND METHODS FOR SELECTIVE PROTEIN EXPRESSION Russian patent published in 2023 - IPC C07K14/725 C07K19/00 C12N15/62 A61P35/00 

Abstract RU 2795467 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the production of fused proteins, and can be used in medicine for the treatment of cancer in the presence of a stabilizing compound. Recombinantly, fusion proteins are produced containing a conditional expression domain, a domain containing a protein of interest, and a protease-cleavable domain separating two domains.

EFFECT: invention makes it possible to obtain fusion proteins characterized by controlled expression depending on the presence of a stabilizing compound in the medium.

68 cl, 47 dwg, 24 tbl, 29 ex

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RU 2 795 467 C2

Authors

Golosov, Andrei

Guimaraes, Carla

Motz, Gregory

Milone, Michael

Ellebrecht, Christoph, T.

Payne, Aimee, S.

Dates

2023-05-03Published

2017-04-14Filed