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(19)

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2 795 467

(13)

(51)

IPC

C07K14/725(2006-01-01)

C07K19/00(2006-01-01)

C12N15/62(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2018140063, 2017-04-14

(24)

Start date

2017-04-14

(22)

Actual filing date

2017-04-14

(45)

Published

2023-05-03

(72)

Inventor

Golosov, AndreiGuimaraes, CarlaMotz, GregoryMilone, MichaelEllebrecht, Christoph, T.Payne, Aimee, S.

(73)

Holder

Novartis AgThe Trustees Of The University Of Pennsylvania

COMPOSITIONS AND METHODS FOR SELECTIVE PROTEIN EXPRESSION Russian patent published in 2023 - IPC C07K14/725 C07K19/00 C12N15/62 A61P35/00

Abstract RU 2795467 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the production of fused proteins, and can be used in medicine for the treatment of cancer in the presence of a stabilizing compound. Recombinantly, fusion proteins are produced containing a conditional expression domain, a domain containing a protein of interest, and a protease-cleavable domain separating two domains.

EFFECT: invention makes it possible to obtain fusion proteins characterized by controlled expression depending on the presence of a stabilizing compound in the medium.

68 cl, 47 dwg, 24 tbl, 29 ex

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RU 2 795 467 C2

Authors

Golosov, Andrei

Guimaraes, Carla

Motz, Gregory

Milone, Michael

Ellebrecht, Christoph, T.

Payne, Aimee, S.

Dates

2023-05-03—Published

2017-04-14—Filed