FIELD: immunology.
SUBSTANCE: disclosed are a CD123-binding domain containing its chimeric antigen receptor (CAR) and a nucleic acid coding receptor. What is also considered is an expression vector expressing a CAR cell and a population of such cells, methods for preparing them. In addition, methods are described for providing antitumour immunity, treating a mammal, preventing CD19-negative recurrence, reducing or depleting the CD123 CAR cells expressing after CAR therapy, as well as a method for exposing an individual to cells of the present invention in preparation for transplantation.
EFFECT: present invention can find further application in therapy of CD123-associated diseases.
101 cl, 75 dwg, 17 tbl, 2 ex
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