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(19)

RU

(11)

2 752 918

(13)

C2

(51)

IPC

C07K14/725(2006-01-01)

C07K16/28(2006-01-01)

C07K19/00(2006-01-01)

C12N15/12(2006-01-01)

C12N15/13(2006-01-01)

C12N15/63(2006-01-01)

C12N5/10(2006-01-01)

A61K35/17(2015-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2017134652, 2016-04-08

(24)

Start date

2016-04-08

(22)

Actual filing date

2016-04-08

(45)

Published

2021-08-11

(72)

Inventor

Bitter, HansBordeaux,Jennifer, MaryBrannetti, BarbaraBrogdon, JenniferDakappagari, Naveen, KumarGill, SaarHighfill, StevenHuang, LuJune, Carl, H.Kim, Ju, YoungLei, MingLi, NaLoew, AndreasOrlando, ElenaRuella, MarcoTran, ThaiZhahg, JiminZhou, Li

(73)

Holder

Novartis AgThe Trustees Of The University Of Pennsylvania

CD20 THERAPY, CD22 THERAPY AND COMBINATION THERAPY WITH CELLS EXPRESSING CHIMERIC ANTIGEN RECEPTOR (CAR) K CD19 Russian patent published in 2021 - IPC C07K14/725 C07K16/28 C07K19/00 C12N15/12 C12N15/13 C12N15/63 C12N5/10 A61K35/17 A61P35/00 

Abstract RU 2752918 C2

FIELD: biotechnology.

SUBSTANCE: isolated molecule of a chimeric antigen receptor that binds CD22 (CD22 CAR) is proposed. Nucleic acids and vectors encoding CD22 CAR are also proposed. In addition, the invention relates to immune effector cells expressing CD22 CAR according to the invention, methods for producing and using such cells for the treatment of mammals with a disease associated with CD22 expression, including for the treatment of cancer.

EFFECT: obtaining immune effector cells for the treatment of mammals with a disease associated with CD22 expression, including cancer.

45 cl, 155 dwg, 43 tbl, 25 ex

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RU 2 752 918 C2

Authors

Bitter, Hans

Bordeaux,Jennifer, Mary

Brannetti, Barbara

Brogdon, Jennifer

Dakappagari, Naveen, Kumar

Gill, Saar

Highfill, Steven

Huang, Lu

June, Carl, H.

Kim, Ju, Young

Lei, Ming

Li, Na

Loew, Andreas

Orlando, Elena

Ruella, Marco

Tran, Thai

Zhahg, Jimin

Zhou, Li

Dates

2021-08-11—Published

2016-04-08—Filed

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