FIELD: biotechnology.
SUBSTANCE: isolated molecule of a chimeric antigen receptor that binds CD22 (CD22 CAR) is proposed. Nucleic acids and vectors encoding CD22 CAR are also proposed. In addition, the invention relates to immune effector cells expressing CD22 CAR according to the invention, methods for producing and using such cells for the treatment of mammals with a disease associated with CD22 expression, including for the treatment of cancer.
EFFECT: obtaining immune effector cells for the treatment of mammals with a disease associated with CD22 expression, including cancer.
45 cl, 155 dwg, 43 tbl, 25 ex
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Authors
Dates
2021-08-11—Published
2016-04-08—Filed