METHOD FOR CORRECTING NEUROLOGICAL DEFICIENCY OF 2-AMINO-5-ETHYL-1,3,4-THIODIAZOLIUM-N-ACETYL-AMINOETHANOATE IN TRAUMATIC BRAIN INJURY Russian patent published in 2021 - IPC A61K31/433 A61P25/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to experimental pharmacology, and is a method for correcting neurological deficits in traumatic brain injury, including modeling a traumatic brain injury in rats by free falling of a load weighing 155 grams from a height of 0.6 m, characterized by the fact that for correction of pathology is administered intragastrically through a probe 2-amino-5-ethyl-1,3,4-thiodiazolium-N-acetyl-aminoethanoate at a dose of 50 mg/kg, once, 30 minutes before modeling the pathology.

EFFECT: effective method for correcting neurological deficits in traumatic brain injury using 2-amino-5-ethyl-1,3,4-thiodiazolium-N-acetyl-aminoethanoate at a dose of 50 mg/kg 30 minutes before modeling the pathology, presumably possessing antioxidant and antihypoxic activity and blocking the activation of free radical processes, as well as lipid peroxidation of cell membranes, in acute disorders of regional and general blood circulation; the method leads to a pronounced correction of the consequences of traumatic brain injury.

1 cl, 4 tbl, 1 ex