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2 766 785

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IPC

A61K31/433(2006-01-01)

G09B23/28(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2021115386, 2021-05-28

(24)

Start date

2021-05-28

(22)

Actual filing date

2021-05-28

(45)

Published

2022-03-15

(72)

Inventor

Martynova Olga ViktorovnaSkachilova Sofiya YakovlevnaCherevatenko Roman FedorovichGureev Vladimir VladimirovichAntsiferov Oleg VladimirovichPeresypkina Anna AleksandrovnaPokrovskij Mikhail VladimirovichSimakina Ekaterina AleksandrovnaShilova Elena VladimirovnaDanilenko Lyudmila MikhajlovnaTrunov Konstantin SergeevichBelyaeva Veronika SergeevnaTsuverkalova Yuliya MikhajlovnaStepenko Yuliya VladimirovnaProskurina Oksana VladimirovnaPokrovskij Vladimir MikhajlovichPatrakhanov Evgenij AleksandrovichEkimova Natalya ViktorovnaMyagkaya Arina AleksandrovnaMostovykh Anna Alekseevna

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD FOR CORRECTION OF PATHOLOGY OF 2-AMINO-5-ETHYL-1,3,4-THIODIAZOLIUM-N-ACETYL-AMINOETHANOATE IN TRAUMATIC BRAIN INJURY Russian patent published in 2022 - IPC A61K31/433 G09B23/28 A61P25/00

Abstract RU 2766785 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology. Method for neurological deficit correction in traumatic brain injury involves simulating a craniocerebral injury in rats by free fall of load of 155 g from height of 0.6 m. For pathology correction, 2-amino-5-ethyl-1,3,4-thiodiazolium-N-acetyl-aminoethanoate is administered intragastrically through 3-day course, in dose of 50 mg/kg, once, for first time 30 minutes beforehand the simulation of pathology, followed by introduction within 2 days.

EFFECT: method leads to pronounced correction of the consequences of the traumatic brain injury.

1 cl, 4 tbl, 1 ex

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RU 2 766 785 C1

Authors

Martynova Olga Viktorovna

Skachilova Sofiya Yakovlevna

Cherevatenko Roman Fedorovich

Gureev Vladimir Vladimirovich

Antsiferov Oleg Vladimirovich

Peresypkina Anna Aleksandrovna

Pokrovskij Mikhail Vladimirovich

Simakina Ekaterina Aleksandrovna

Shilova Elena Vladimirovna

Danilenko Lyudmila Mikhajlovna

Trunov Konstantin Sergeevich

Belyaeva Veronika Sergeevna

Tsuverkalova Yuliya Mikhajlovna

Stepenko Yuliya Vladimirovna

Proskurina Oksana Vladimirovna

Pokrovskij Vladimir Mikhajlovich

Patrakhanov Evgenij Aleksandrovich

Ekimova Natalya Viktorovna

Myagkaya Arina Aleksandrovna

Mostovykh Anna Alekseevna

Dates

2022-03-15—Published

2021-05-28—Filed