APPLICATION OF 2-[(R-BENZYLIDENE)HYDRAZONO]-8-HYDROXY-6-(2-HYDROXYPHENYL)-9-AROYL-1-THIA-3,6-DIAZASPIRO[4.4]NONA-8-EN-4,7-DIONES AS AGENTS WITH ANTI-INFLAMMATORY ACTIVITY Russian patent published in 2022 - IPC C07D513/10 A61K31/438 A61P29/00 

Abstract RU 2783241 C1

FIELD: organic chemistry and pharmaceuticals.

SUBSTANCE: invention relates to the field of organic chemistry and pharmaceuticals, and in particular to the use of compounds of the class 2-[(R-benzylidene)hydrazono]-8-hydroxy-6-(2-hydroxyphenyl)-9-aroyl-1-thia-3,6-diazaspiro[4.4]nona-8-en-4,7-diones. The use of 2-[(R-benzylidene)hydrazono]-8-hydroxy-6-(2-hydroxyphenyl)-9-aroyl-1-thia-3,6-diazaspiro[4.4]nona-8-en-4,7 is disclosed -diones, where R=R1=H(a), R=CH3, R1=F(b), as anti-inflammatory agents.

EFFECT: invention provides a pronounced anti-inflammatory effect.

1 cl, 1 tbl, 3 ex

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RU 2 783 241 C1

Authors

Mashevskaia Irina Vladimirovna

Lukmanova Dzhamilia Nailevna

Apushkin Danila Iurevich

Utushkina Taisiia Andreevna

Iakushina Karolina Evgenevna

Andreev Aleksandr Igorevich

Dates

2022-11-10Published

2022-02-28Filed